Rivaroxaban Versus Warfarin in Patients with Mechanical Heart Valves: Open-Label, Proof-of-Concept trial —The RIWA study

ConclusionsIn this pilot study, rivaroxaban 15  mg twice daily had thromboembolic and bleeding events similar to warfarin in patients with mechanical heart valves. These data confirm the authors’ proof-of-concept and suggest that a larger trial with a similar design is not unreasonable.ClinicalTrial.gov identifierNCT03566303.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research

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In conclusion, we found that activated PERK during MI contributed to arrhythmia risk by the downregulation of select cardiac ion channels. PERK inhibition prevented these changes and reduced arrhythmia risk. These results suggest that ion channel downregulation during MI is a fundamental arrhythmia mechanism and that maintenance of ion channel levels is antiarrhythmic.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Journal of Hepatology - Category: Gastroenterology Source Type: research
ConclusionBased on available information on pathophysiology and treatment of FH-1 in pregnancy, recommendations for the rational management of FH-1 in pregnancy are provided.
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionCompared with euthyroid status, hypothyroid status has an independent predicting value for adverse cardiovascular events in AMI patients. Further investigations are required to illustrate whether treatment of thyroid dysfunction could improve the prognosis of AMI patients.
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionsThis study shows that vitamin D3 content is associated with the incidence of diabetes in people with high level of uric acid. This study offers a fresh perspective on the elements that influence the etiology of diabetes in hyperuricemia patients.
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractObjectivesTo analyze the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents, including mediating pathways triggered by their common risk factors.Materials and methodsUsing a population-based sample study (n = 405) of Brazilian adolescents (17 –18 years old), direct and mediation pathways triggered by “Socioeconomic Status,” “Adiposity,” Smoking, and “Blood Pressure” were modelled for the association between the “Systemic Circulating Inflammatory Burden of CVD Risk” (IL-1β, IL-6, IL-8, TNF-&...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
ConclusionsSurgical and non-surgical debridement for the treatment of peri-implantitis present similar clinical outcomes. Bone levels were better improved in ST than NST for sites with higher initial bone loss.Clinical relevanceThe treatment of peri-implantitis is still a challenge in clinical practice, since less than half of affected implants achieve health after surgical or non-surgical debridement. Considering the lack of clinically relevant differences between these two treatments, non-surgical debridement should be considered the first therapeutic choice for peri-implantitis, mainly mild to moderate cases.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
For patients with large hemorrhagic brain lesions caused by CVT, who are at a very high risk for death, decompressive surgery was associated with remarkably good outcomes in the DECOMPRESS2 study.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
VITAMIN B12 deficiency can cause some serious - and seriously unpleasant - side effects, including your dental hygiene. Do you have this oral symptom of B12 deficiency?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
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