Cancers, Vol. 12, Pages 3082: Is There A Causal Relationship between Childhood Obesity and Acute Lymphoblastic Leukemia? A Review

We describe possible mechanisms, including adipose tissue attraction and protection of lymphoblasts, and their impact on ALL chemotherapies’ pharmacokinetics. We also explore the potential contribution of cytokines, growth factors, natural killer cells and adipose stem cells to ALL initiation and propagation. While there are no current definite causal links between obesity and ALL, critical questions persist as to whether the adipose tissue microenvironment and endocrine actions can play a causal role in childhood ALL, and there is a need for more research to address these questions.

Source: Cancers - October 22, 2020 Category: Cancer & Oncology Authors: Molly J. Dushnicky Samina Nazarali Adhora Mir Carol Portwine Muder Constantine Samaan Tags: Review Source Type: research