Cancers, Vol. 12, Pages 2961: Vascular Complications in Patients with Hepatocellular Carcinoma Treated with Sorafenib
Cancers, Vol. 12, Pages 2961: Vascular Complications in Patients with Hepatocellular Carcinoma Treated with Sorafenib
Cancers doi: 10.3390/cancers12102961
Authors:
Katharina Pomej
Bernhard Scheiner
Dabin Park
David Bauer
Lorenz Balcar
Tobias Meischl
Mattias Mandorfer
Thomas Reiberger
Christian Müller
Michael Trauner
Matthias Pinter
VEGF(R)-targeted therapies are associated with an increased risk of thromboembolism and bleeding, which might be pronounced in patients with increased cardiovascular risk. Nevertheless, sorafenib represents an important treatment option in patients with hepatocellular carcinoma (HCC). We retrospectively investigated the risk of arterial/venous thromboembolic and bleeding events in 252 patients treated with sorafenib for HCC between 05/2006 and 03/2020 at the Medical University of Vienna. Cardiovascular risk was assessed using Framingham score. Eight patients (3.2%) experienced 11 arterial/venous thromboembolic events. Only two patients (0.8%) developed arterial thromboembolism even though cardiovascular risk was low, intermediate, and high in 15 (8.7%), 104 (60%), and 54 (31.2%) of 173 assessable patients. Median overall survival (OS) was shorter in the high risk vs. low/intermediate risk group 7.4 (95% CI: 3.4–11.3) vs. 10.0 (95% CI: 6.8–13.2 months) and independently associated with OS in multivariable analysis HR: 1.53 (95% CI: 1.07–2.19; p = 0.019). Forty-eight (19%) patient...
Source: Cancers - Category: Cancer & Oncology Authors: Katharina Pomej Bernhard Scheiner Dabin Park David Bauer Lorenz Balcar Tobias Meischl Mattias Mandorfer Thomas Reiberger Christian M üller Michael Trauner Matthias Pinter Tags: Article Source Type: research
More News: Bleeding | Cancer | Cancer & Oncology | Carcinoma | Cardiology | Cardiovascular | Epistaxis (Nosebleeds) | Gastroenterology | Heart | Hepatocellular Carcinoma | Liver | Liver Cancer | Liver Disease | Thrombosis | Urology & Nephrology