The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid cancer patients: a systematic review and meta-analysis.

The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid cancer patients: a systematic review and meta-analysis. Thyroid. 2020 Oct 03;: Authors: Piek MW, Postma EL, van Leeuwaarde R, de Boer JP, Bos AME, Lok C, Stokkel M, Filipe M, van der Ploeg IMC Abstract Introduction Thyroid cancer is one of the most common carcinomas diagnosed in adolescents and young adults (AYA), with a rapidly rising incidence over the past three decades. Surgery is the standard treatment for patients with differentiated thyroid carcinoma (DTC), and when indicated, followed by radioactive iodine (RAI) treatment. The aim of this study was to evaluate the possible effects of RAI therapy on ovarian function and fertility in women. Methods The PubMed, Embase and Web of Science databases were systematically searched up to Jan 2020. Additionally, a meta-analyses were performed for anti-Mullerian hormone (AMH) levels after RAI, comparison of AMH levels prior and one year after RAI, and pregnancy rates in patient with thyroid cancer receiving RAI compared to patients with thyroid cancer who did not receive RAI. Results A total of 36 studies were eligible for full-text screening and 22 studies were included. The majority of the studies had a retrospective design. Menstrual irregularities were present in the first year after RAI in 12% and up to 31% of the patients. Approximately 8% - 16% of the patients experienced amenorrhea in the first year after RAI....
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research

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