HDAC6 is critical for ketamine-induced impairment of dendritic and spine growth in GABAergic projection neurons.

This study reveals a novel role of HDAC6 as a regulator for ketamine-induced deficits in the morphological development of MSNs and provides an innovative method for prevention and treatment with respect to ketamine clinical applications.
PMID: 32939037 [PubMed - as supplied by publisher]

Source: Acta Pharmacologica Sinica - September 15, 2020 Category: Drugs & Pharmacology Authors: Li X, Saiyin H, Zhou JH, Yu Q, Liang WM Tags: Acta Pharmacol Sin Source Type: research