Cancers, Vol. 12, Pages 2671: Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth

Cancers, Vol. 12, Pages 2671: Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth Cancers doi: 10.3390/cancers12092671 Authors: Claudia B. Colon-Echevarria Tatiana Ortiz Lizette Maldonado Melanie J. Hidalgo-Vargas Jaileene Pérez-Morales Alexandra N. Aquino-Acevedo Roberto Herrera-Noriega Margarita Bonilla-Claudio Eida M. Castro Guillermo N. Armaiz-Pena Multiple studies suggest that chronic stress accelerates the growth of existing tumors by activating the sympathetic nervous system. Data suggest that sustained adrenergic signaling can induce tumor growth, secretion of pro-inflammatory cytokines, and macrophage infiltration. Our goal was to study the role of adrenergic-stimulated macrophages in ovarian cancer biology. Cytokine arrays were used to assess the effect of adrenergic stimulation in pro-tumoral cytokine networks. An orthotopic model of ovarian cancer was used to assess the in vivo effect of daily restraint stress on tumor growth and adrenergic-induced macrophages. Cytokine analyses showed that adrenergic stimulation modulated pro-inflammatory cytokine secretion in a SKOV3ip1 ovarian cancer cell/U937 macrophage co-culture system. Among these, platelet-derived growth factor AA (PDGF-AA), epithelial cell-derived neutrophil-activating peptide (ENA-78), Angiogenin, vascular endothelial growth factor (VEGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research