GEO Data Sets Analysis Identifies COX-2 and Its Related Micro RNAs as Biomarkers for Non-Ischemic Heart Failure

In this study, we analyzed the genomic and transcription data of HF peripheral blood mononuclear cell (PBMC) samples obtained from the Gene Expression Omnibus data sets using Omicsbean online database (http://www.omicsbean.cn/) and found that the prostaglandin-endoperoxide synthase 2 (PTGS2), also named as cyclooxygenase-2 (COX-2), as well as its related micro RNAs including miR-1297 and miR-4649-3p might be used as potential biomarkers for non-ischemic heart failure. Our result showed that plasma COX-2 and miR-4649-3p were significantly up-regulated, whereas the plasma miR-1297 was significantly decreased, and miR-4649-3p displayed high predictive power for non-ischemic heart failure.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Conclusions: This large matched-cohort study identified the minimum weight loss thresholds for reduction in risk of MACE and all-cause mortality in patients with obesity and diabetes. Furthermore, in our analysis, the effect of surgery was still present after accounting for weight loss, which may suggest the presence of weight-independent beneficial effects of metabolic surgery on MACE and survival.
Source: Annals of Surgery - Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE AMERICAN SURGICAL ASSOCIATION Source Type: research
Patients with end-stage heart failure (ESHF) treated with ventricular assist devices (VADs) tend to gain weight after implantation, which is associated with higher complication rates and is a contraindication ...
Source: BMC Research Notes - Category: Research Authors: Tags: Data note Source Type: research
WEDNESDAY, Sept. 16, 2020 -- Severe obesity in organ donors is not associated with adverse heart transplant outcomes, according to a study published online Sept. 16 in Circulation: Heart Failure. Elizabeth D. Krebs, M.D., from the University of...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionOptimizing blood glucose level during the perioperative period with correct medication and dose have a significant role in reducing morbidities. Measures should be taken to provide a safe blood glucose level for optimum outcomes.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractIn patients with heart failure with preserved ejection fraction (HFpEF), diabetes mellitus (DM) and obesity are important comorbidities as well as major risk factors. Their conjoint impact on the myocardium provides insight into the HFpEF aetiology. We sought to investigate the association between obesity, DM, and their combined effect on alterations in the myocardial tissue in HFpEF patients. One hundred and sixty-two HFpEF patients (55  ± 12 years, 95 men) and 45 healthy subjects (53 ± 12 years, 27 men) were included. Patients were classified according to comorb...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
ConclusionMost studies focused on clinical trial outcomes, such as cardiovascular death and heart failure (HF) hospitalization. The mechanisms of SGLT2 inhibitors, especially those related to cardiac metabolism, may soon become hotspots and should be closely monitored.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study sought to determine if body mass index (BMI) impacts the treatment effects or safety outcomes of the treatment of ischaemic heart failure with coronary artery bypass graftin g (CABG).Methods and resultsWe obtained and reviewed the Surgical Treatment of Ischaemic Heart Failure (STICHES) data for 1212 patients. We categorized obesity by the World Health Organization (WHO) classes to define baseline characteristics and test for treatment interactions for the primary and secondary STICHES outcomes by treatment groups. While CABG decreased the risk of death, there was no evidence of treatment interaction by BMI per 5...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Short Communication Source Type: research
ConclusionsThere was a high prevalence (61%) of subclinical cardiac dysfunction in obesity patients without known cardiovascular disease, which appeared to be best identified by GLS. Subclinical cardiac dysfunction in obesity was linked to autonomic dysfunction and male gender, and not to the presence of traditional cardiac risk factors, increased C ‐reactive protein, increased BNP, increased high‐sensitivity troponin I, or increased left ventricular mass.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Obesity is a major independent risk factor for premature death due to cardiovascular diseases. Several studies have reported a better prognosis for obese patients who underwent transcatheter aortic valve replacement, coronary artery bypass grafting, hypertension, and heart failure compared with their leaner counterparts.1,2 This counterintuitive phenomenon has been described as an “obesity paradox,” and the exact pathophysiological mechanism of this association is not fully understood. Mitral regurgitation (MR) is the most frequent form of valvular heart disease in the United States.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Obesity is a major independent risk factor for premature death due to cardiovascular diseases. Several studies have reported a better prognosis for obese patients undergoing transcatheter aortic valve replacement, coronary artery bypass grafting, hypertension, and heart failure compared to their leaner counterparts.1,2 This counterintuitive phenomenon has been described as an “obesity paradox”, and the exact pathophysiological mechanism of this association is not fully understood. Mitral regurgitation (MR) is the most frequent form of valvular heart disease in the United States.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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