Genetic investigation of nodal melanocytic nevi in cases of giant congenital melanocytic nevus.

Genetic investigation of nodal melanocytic nevi in cases of giant congenital melanocytic nevus. Histol Histopathol. 2020 Jul 30;:18243 Authors: Cao Y, Yang X, Lai YM, Jia L, Diao XT, Zhuang Q, Lin DM Abstract Nodal melanocytic nevi are common incidental findings in lymph nodes that have been removed during sentinel lymph node biopsy for melanoma. They can also occur in the local lymph nodes of the giant congenital nevus (GCN), but very little is known regarding nodal melanocytic nevi in the giant congenital nevus, especially at the genetic level. There are two theories that explain the possible pathogenesis of nodal melanocytic nevi, mechanical transport and arrested migration during embryogenesis. However, there have been few tests of these two theories at the molecular biology level until now. We used whole-exon sequencing to test these two theories at the gene level for the first time. In clonal evolution analysis of patient 1, whose tumor mutation burden (TMB) value was relatively stable, showed that the GCN and nodal nevus had the same initial origin and then diverged into two branches as a result of gene mutations. In contrast, analysis indicated that in the other patient, whose TMB value declined from 68.02/Mb in a GCN to 17.55/Mb in associated nodal nevi, these two samples were from different origins at the beginning, each with its own gene mutation. These results are consistent with the two respective theories at the molecul...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research