Impact of β-glycerophosphate on the bioenergetic profile of vascular smooth muscle cells

In conclusion, β-glycerophosphate modifies key parameters of mitochondrial function and cellular bioenergetics in VSMCs that may contribute to the onset of phenotypical transdifferentiation and calcification. These observations advance the unde rstanding of the role of energy metabolism in VSMC physiology and pathophysiology of vascular calcification during hyperphosphatemia.Key messagesβ-Glycerophosphate modifies key parameters of mitochondrial respiration in VSMCs.β-Glycerophosphate induces changes in mitochondrial fuel choice in VSMCs.β-Glycerophosphate promotes a more oxidative and less glycolytic phenotype of VSMCs.β-Glycerophosphate triggers mitochondrial-dependent oxidative stress in VSMCs.Bioenergetics impact β-glycerophosphate-induced VSMC calcification.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research