Cancers, Vol. 12, Pages 1398: Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord –Stromal Tumors: A Contemporary Review

Cancers, Vol. 12, Pages 1398: Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord–Stromal Tumors: A Contemporary Review Cancers doi: 10.3390/cancers12061398 Authors: Asaf Maoz Koji Matsuo Marcia A. Ciccone Shinya Matsuzaki Maximilian Klar Lynda D. Roman Anil K. Sood David M. Gershenson Non-epithelial ovarian tumors are heterogeneous and account for approximately 10% of ovarian malignancies. The most common subtypes of non-epithelial ovarian tumors arise from germ cells or sex cord and stromal cells of the gonads. These tumors are usually detected at an early stage, and management includes surgical staging and debulking. When indicated for advanced disease, most respond to chemotherapy; however, options for patients with refractory disease are limited, and regimens can be associated with significant toxicities, including permanent organ dysfunction, secondary malignancies, and death. Targeted therapies that potentially decrease chemotherapy-related adverse effects and improve outcomes for patients with chemotherapy-refractory disease are needed. Here, we review the molecular landscape of non-epithelial ovarian tumors for the purpose of informing rational clinical trial design. Recent genomic discoveries have uncovered recurring somatic alterations and germline mutations in subtypes of non-epithelial ovarian tumors. Though there is a paucity of efficacy data on targeted therapies, such as kinase inhibitors, antib...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research