Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors

ConclusionsDuring early neuronal differentiation, there are consistent and time-point specific proteomic alterations in RTT patient cells carrying exons 3 –4 deletion inMECP2. We found changes in proteins involved in pathway associated with RTT phenotypes, including dendrite morphology and synaptogenesis. Our results provide a valuable resource of proteins and pathways for follow-up studies, investigating common mechanisms involved during early disease stages of RTT syndrome.
Source: Molecular Autism - Category: Molecular Biology Source Type: research