Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy

Cardiolipin (CL) is a unique tetra-acyl phospholipid localized to the inner mitochondrial membrane and essential for normal respiratory function. It has been previously reported that the failing human heart and several rodent models of cardiac pathology have a selective loss of CL. A rare genetic disease, Barth syndrome (BTHS), is similarly characterized by a cardiomyopathy due to reduced levels of cardiolipin. A mouse model of cardiolipin deficiency was recently developed by knocking-down the cardiolipin biosynthetic enzyme tafazzin (TAZ KD).

Source: Journal of Molecular and Cellular Cardiology - May 9, 2020 Category: Cytology Authors: Laura K. Cole, Edgard M. Mejia, Genevieve C. Sparagna, Marilyne Vandel, Bo Xiang, Xianlin Han, Nikolaos Dedousis, Brett A. Kaufman, Vernon W. Dolinsky, Grant M. Hatch Source Type: research