Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification

Inflammation is implicated in the pathogenesis of calcific aortic valve disease (CAVD) which is a major contributor to cardiovascular mortality and lacks non-surgical treatment. The progranulin (PGRN) is an important immunomodulatory factor in a variety of inflammatory diseases, including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease and pneumonia. However, its role in calcification of aortic valve remains unknown.We firstly found that PGRN was increased in calcified human aortic valve (AV) tissues.

Source: Journal of Molecular and Cellular Cardiology - April 1, 2020 Category: Cytology Authors: Gaigai Huang, Liqin An, Mengtian Fan, Menghao Zhang, Bin Chen, Mengying Zhu, Jinghong Wu, Yan Liu, Yue Wang, Qin Huang, Qiong Shi, Yaguang Weng Source Type: research