Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease [Medical Sciences]

Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes...

Source: Proceedings of the National Academy of Sciences - March 30, 2020 Category: Science Authors: Panu K. Luukkonen, Sylvie Dufour, Kun Lyu, Xian–Man Zhang, Antti Hakkarainen, Tiina E. Lehtimaki, Gary W. Cline, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki–Jarvinen Tags: Biological Sciences Source Type: research