The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman   Pinschers of efficacy and outcomes

ConclusionsTreatment with BC 007 for β1‐AAB neutralization was safe, resulted in a long‐lasting reduction of β1‐AAB combined with improved cardiac function and prolonged the survival of DP with DCM. Using a natural large animal model of DCM considered superior to small animal models of immunization‐induced cardiomyopathy, com bined with a study design comparable with clinical trials, we believe that our results provide the basis for optimism that treatment with BC 007 might also be effective in human patients with DCM.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research