Clinical utility of characterizing intestinal flora in septic kidney injury.

Clinical utility of characterizing intestinal flora in septic kidney injury. Chin Med J (Engl). 2020 Mar 06;: Authors: Yuan JJ, Chang XN, Li M, Yuan QX, Yang XL Abstract The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such changes further influence the occurrence and development of AKI. Understanding of the intestinal flora is increasing rapidly. The literature shows that cardiovascular cerebrovascular, digestive-system, respiratory and immune diseases, among others, as well as cancer, and the requirement for liver transplantation are all related to an imbalance in the intestinal flora. New technology is enabling various detection methods for intestinal flora. Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis, disease progression mechanism, and intestinal flora. PMID: 32149763 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research