5 Things That Will Dominate The 2020s For Pharma Companies

What’s worth some 1,204.8 billion USD? Well, it’s the worldwide pharmaceutical market, of course! With such a capital at stake and with the pace of technological disruption, the pharma industry is quick to adapt to the changing times. In fact, leading drug companies are re-investing as much as 20.8% of drug sales into new drug development.  We’ve analyzed the trends shaping the future of pharma before, but how can we expect to see the landscape evolve in this new decade? With leaps in A.I., patient empowerment and 3D printed drugs, here are the 5 aspects that will be the focus of pharmaceutical companies in the coming years. 1. Faster and cheaper: A.I. for drug R&D A recent report forecasts the global artificial intelligence in healthcare market size to reach the USD 31.3 billion bar by 2025, growing at a compound annual growth rate (CAGR) of 41.5% over a forecast period. Pharma companies’ contribution to this growth isn’t negligible, as the sheer amount of A.I. companies in drug development reflects. It’s all about the speed and savings that A.I. ‘s myriad of applications can bring in this sector. Source: https://medsocial.ai/ Companies like Atomwise, Turbine and Deep Genomics use artificial intelligence to identify the most suitable drugs for certain conditions, doing so in record time all while cutting down on the costs. A prime example is that of Atomwise providing its algorithm to perform the drug research in ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Pharma digital health future of medicine pharmaceutics digital health companies Source Type: blogs

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Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
The absence of alloantibodies is a feature of transplantation tolerance. Although the lack of T cell help has been evoked to explain this absence, herein we provide evidence for B cell–intrinsic tolerance mechanisms. Using a murine model of heart tolerance, we showed that alloreactive B cells were not deleted but rapidly lost their ability to differentiate into germinal center B cells and secrete donor-specific antibodies. We inferred that tolerant alloreactive B cells retained their ability to sense alloantigen because they continued to drive T cell maturation into CXCR5+PD-1+ T follicular helper cells. Unexpectedly...
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We reported that, while autophagy was necessary for β cell survival, the highly conserved Sel1L-Hrd1 ERAD protein complex was required for the maintenance of β cell maturation and identity. Using single-cell RNA-Seq, we demonstrated that Sel1L deficiency was not associated with β cell loss, but rather loss of β cell identity. Sel1L-Hrd1 ERAD controlled β cell identity via TGF-β signaling, in part by mediating the degradation of TGF-β receptor 1. Inhibition of TGF-β signaling in Sel1L-deficient β cells augmented the expression of β cell maturation markers and increased the t...
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