Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
Publication date: Available online 22 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Kimiyasu Shiraki, Tohru DaikokuAbstractFavipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing animals with lethal infection. In addition to influenza, favipiravir has a broad spectrum of anti-RNA virus activities in vitro and efficacies in animal models with lethal RNA viruses and has been used for treatment of human infection with life-threatening Ebola virus, Lassa virus, rabies, and severe fever with thrombocytopenia syndrome. The best feature of favipiravir as an antiviral agent is the apparent lack of generation of favipiravir-resistant viruses. Favipiravir alone maintains its therapeutic efficacy from the first to the last patient in an influenza pandemic or an epidemic lethal RNA virus infection. Favipiravir is expected to be an important therapeutic agent for severe influenza, the next pandemic influenza strain, and other severe RNA virus infections for which standard treatments are not available.
Conclusions: Clinical symptoms and spinal fusion efficiency were not significantly different between CBT and PS except for postoperative improvement in low back pain. The treatment effect on postoperative low back pain was smaller for CBT than for PS. PMID: 32213798 [PubMed - as supplied by publisher]
We present a case series to illustrate a new treatment paradigm utilizing front line EMS Paramedic units and high dose buprenorphine to treat withdrawal symptoms with next day bridge to long term care. The three patients described are exemplary cases, meant to represent overall characteristics of the intervention prior to complete data collection. Each patient was revived from opioid overdose with naloxone. Paramedics then treated each patient with 16 mg of buprenorphine to relieve and prevent withdrawal symptoms. Patients were provided with outpatient follow up irrespective of ED transport. To the best of our knowl...
Mali records first death ahead of election and Trump considers New York quarantine. This blog is now closedCoronavirus – latest updatesSee all our coronavirus coverage11.55pmGMTI ’ll be handing over to my colleagues in Australia shortly, but before I go, here’s a summary of the key coronavirus developments in the last few hours:Related:Coronavirus live news: Trump proposes 'quarantine' of New York and other hotspots11.18pmGMTBritons stranded in New Zealand are facing costs of £40,000 to return home, my colleagueMark Townsend reported.Those stranded say they have been left without guidance or assista...
Spine Intervention Society - COVID-19 Resources for Members Guidance on Interventional Pain Procedures During the COVID-19 Global Emergency When planning for interventional pain procedures during the COVID-19 emergency, consider the Centers for Disease Control and Prevention (CDC) statement regarding goals for the U.S. healthcare system in response to COVID-19: Reduce morbidity and mortality Minimize disease transmission Protect healthcare personnel... SIS Guidance on Spinal Procedures During COVID-19 Pandemic
COVID-19 has already become a once-in-a-lifetime event that has fundamentally impacted US healthcare, and EM is at the frontlines of it all. I'm wondering how this pandemic will affect the trends of EM residency applications for this coming cycle and the ones to follow. Will even more medical students flock to EM, because they'll be motivated by witnessing how crucial EM physicians are in a time of crisis? Or will the application numbers fall, because more students will realize how... How do you think COVID will affect EM residency application trends?
Jack Iwashyna Should we put multiple COVID-19 patients on a single ventilator? Prof Jack Iwashyna on the highly limited role of single ventilator / multiple patient workarounds in the COVID-19 epidemic.
Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
Insurance premiums could spike as much as 40 percent next year, a new analysis warns, as employers and insurers confront the projected tens of billions of dollars in additional costs of treating coronavirus patients.
Publication date: Available online 27 March 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Gavin Giovannoni, Chris Hawkes, Jeannette Lechner-Scott, Michael Levy, Emmanuelle Waubant, Julian Gold
CONCLUSION: A significant positive relationship was observed between sucrose in coffee and tea and the number of coronal or root caries lesions in community-dwelling elderly Japanese. PMID: 32212434 [PubMed - as supplied by publisher]