Monitoring CD8a + T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [ 64 Cu]NOTA-CD8a PET Imaging

ConclusionIn the present study, we demonstrated that [64Cu]NOTA-CD8a was able to detect treatment-induced changes in CD8a+ infiltration in murine CT26 colon tumors following a common preclinical combination treatment protocol. Overall, [64Cu]NOTA-CD8a exhibited good prognostic and predictive value. We suggest that [64Cu]NOTA-CD8a PET imaging can be used as an early biomarker of response to therapy in preclinical models.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research