Paraneoplastic Cerebellar Degeneration in Diffuse Large B-cell Lymphoma and Review of associated Onconeural Antibodies

Publication date: Available online 19 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Vasu Saini, Aditi Dhir, Ariana W. Rudnick, Joshua Lukas, Karlo J. Lizarraga, Jason Margolesky, Deborah O. Heros, James E. HoffmanAbstractParaneoplastic neurologic syndromes are rare but well described presentation of certain malignancies in both children and adults. Cerebellar dysfunction is a common paraneoplastic presentation and has been previously reported in association with small cell lung cancer, breast cancers, ovarian tumors, renal cell carcinoma, follicular lymphoma, and Hodgkin’s lymphoma. There are only a handful of case reports with the association of paraneoplastic neurologic presentation with Non-Hodgkin lymphoma including Diffuse Large B-cell Lymphoma (DLBCL). Herein we describe a case of a 66-year-old woman who presented with a subacute, progressive syndrome of cerebellar dysfunction antecedent to painless lymphadenopathy and subgaleal mass with the subsequent diagnosis of stage IV DLBCL, along with a literature review of onconeural antibodies. Onconeural antibodies associated with paraneoplastic cerebellar degeneration can have a prognostic value and furthermore, their specificity to certain cancers can help guide prompt diagnosis.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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