Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy

Publication date: May 2020Source: Biomedicine &Pharmacotherapy, Volume 125Author(s): Da-Hye Lee, So-Hyun Park, Yang Hoon Huh, Min Jung Kim, Hyo-Deok Seo, Tae-Youl Ha, Jiyun Ahn, Young-Jin Jang, Chang Hwa JungAbstractNonalcoholic fatty liver disease (NAFLD) is a common risk factor for metabolic syndrome that increases the risk of future cardiovascular disease, stroke, and diabetes. Recently, autophagy has been proposed as a means to prevent NAFLD. We investigated whether substances with autophagy-inducing activity alleviate NAFLD. The Valeriana fauriei (V. fauriei) was selected as a potential autophagy inducer among various natural materials using a Cyto-ID autophagy detection kit. V. fauriei 70 % ethanol extract (VFE) increased LC3II levels in the presence of the lysosomal inhibitor and reduced the GFP/mCherry puncta ratio, suggesting that VFE enhanced autophagy. VFE reduced oleic acid (OA)-induced lipid accumulation and increased the number of autophagosome in hepatocytes. Autophagy induction by VFE is due to inhibition of mTORC1 activity. VFE supplementation reduced fatty liver by downregulating lipogenesis-related genes and increased the autophagy, as revealed by TEM and IHC analysis in the fatty liver. We identified iridoids as main compounds of VFE; didrovaltrate (DI), valeriotriate B (VAL B), valeriotetrate C (VAL C), valtrate (VAL), and valechlorine (VC) were shown to enhance autophagy. These compounds also reduced OA-induced lipid accumulation in an Atg5-dependent...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
Soares Albuquerque Indiara Penido Tayrine Araujo Santos Ana Paula Dinis Ano Bom Andrea Marques Vieira da Silva Camilla Bayma Fernandes Carlos Eduardo Calzavara Erna Geessien Kroon Olindo Assis Martins-Filho Andréa Teixeira-Carvalho Betânia Paiva Drumond One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver ...
Source: Viruses - Category: Virology Authors: Tags: Case Report Source Type: research
Abstract Nonalcoholic fatty liver disease (NAFLD) is a common risk factor for metabolic syndrome that increases the risk of future cardiovascular disease, stroke, and diabetes. Recently, autophagy has been proposed as a means to prevent NAFLD. We investigated whether substances with autophagy-inducing activity alleviate NAFLD. The Valeriana fauriei (V. fauriei) was selected as a potential autophagy inducer among various natural materials using a Cyto-ID autophagy detection kit. V. fauriei 70 % ethanol extract (VFE) increased LC3II levels in the presence of the lysosomal inhibitor and reduced the GFP/mCherry puncta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study. Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday. After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Disease Source Type: news
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - Category: Biomedical Science Tags: Arch Med Sci Source Type: research
Abstract BackgroundNon‐alcoholic fatty liver disease (NAFLD) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance, and type 2 diabetes mellitus (T2DM). We sought to assess the association between a specific stroke subgroup, brainstem infarctions (BSIs), and NAFLD. Furthermore, we evaluated whether NAFLD is an independent risk factor in patients with BSIs. MethodsNAFLD was assessed in 306 radiologically confirmed BSIs patients via liver ultrasound. Differences between patients with and without NAFLD were compared. Data associated with stroke severity and progression after admission was collected. R...
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research
This study was designed to assess the correlation between NAFLD as a cardiovascular risk factor and carotid atherosclerosis. Patients and methods A hospital-based case–control analytical study was conducted on 60 participants who were divided into three groups as follows. Group I included 20 diabetic patients with NAFLD. Group II included 20 nondiabetic patients with NAFLD. Group III included 20 healthy participants who served as a control group. The right and left carotid intima-media thickness (CIMTs) and their maximum reading (CIMTmax) was measured by a skilled sonographer blind to the groups. Pelviabdominal ul...
Source: Egyptian Liver Journal - Category: Gastroenterology Tags: Original articles Source Type: research
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