Induction of Anti-PEG Immune Responses by PEGylation of Proteins.

[Induction of Anti-PEG Immune Responses by PEGylation of Proteins]. Yakugaku Zasshi. 2020;140(2):163-169 Authors: Shimizu T, Ishima Y, Ishida T Abstract Modification of proteins with polyethylene glycol (PEG) (PEGylation) is a gold standard technique that improves the solubility, pharmacokinetics, and immunogenicity of modified proteins. To date more than 10 PEGylated protein formulations have been approved, and more than 20 PEGylated drugs are entering clinical trials. PEG has been considered non-immunogenic and non-toxic, but several studies have shown that PEG acquires immunogenicity following attachment to nanoparticles. The administration of PEGylated liposomes, micelles and proteins induces the production of antibodies against PEG (anti-PEG antibodies) in animals and human subjects. Indeed, approximately 20% of healthy human subjects possess pre-existing anti-PEG antibodies prior to treatment with PEGylated therapeutics. The induced and pre-existing anti-PEG antibodies cause not only the elimination of PEGylated proteins from blood circulation, but also allergic responses via the release of anaphylatoxins. Consequently, therapeutic outcomes for PEGylated proteins are impaired. The utility of PEGylated proteins could be improved by attenuating the PEG-related immune response. On the other hand, anti-PEG immune responses might be exploited for vaccine applications. Our recent studies demonstrated that anti-PEG antibodies mediate the delivery of antig...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research

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Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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Source: virology blog - Category: Virology Authors: Tags: Uncategorized ACE2 antiviral coronavirus COVID-19 mouse model SARS-CoV-2 spike glycoprotein vaccine virology viruses Source Type: blogs
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Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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