DKK3 expression and function in head and neck squamous cell carcinoma and other cancers

ConclusionOur previously published data, alongside those from other reports, indicate that DKK3 may have an additional oncogenic function other than tumor suppression.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research

Related Links:

AbstractBackgroundDocetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy (ICT) is a treatment option for locally advanced unresectable head and neck squamous cell carcinoma (LA-HNSCC). However, patients with advanced age, or renal, cardiac or neurogenic dysfunction are ineligible for ICT-TPF.MethodsWe retrospectively assessed 24 unresectable LA-HNSCC patients who received paclitaxel, carboplatin and cetuximab (PCE) as ICT at the Shizuoka Cancer Center between April 2013 and October 2018.ResultsPatient characteristics were as follows: median age, 72  years (range 60–81); 0, 1, and 2 performance sta...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: In comparison to the results from the Western countries, the prevalence of HPV-related HNSCC in Thai patients was less, and differences in some characteristics were observed. Nevertheless, improvement in OS, DFS and LRFS were observed in p16-positive patients. Our analyses suggested that p16 status is also a strong prognostic marker for HNSCC patients in Thailand. PMID: 32592364 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
(Impact Journals LLC) Volume 11 Issue 25 of @Oncotarget reported that the authors aimed to characterize the bacteriome, mycobiome, and mycobiome-bacteriome interactions of oral wash in Head and neck squamous cell carcinoma, or HNSCC, patients and to determine if they are distinct from those of the oral wash of matched non-Head and neck squamous cell carcinoma patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In this study, we investigated the effect of the DNA demethylation agent 5-AZA-2 ’-deoxycytidine (5-AZA) over HNSCC and its population of cancer stem cells (CSCs) presenting dysfunctional PTEN.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
AbstractObjectivesHead and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. The aim of this study was to develop and validate MRI-based radiomic prognostic models in oral and oropharyngeal cancer.Materials and MethodsNative T1-weighted images of four independent, retrospective (2005 –2013), patient cohorts (n = 102,n = 76,n = 89, andn = 56) were used to delineate primary tumors, and to extract 545 quantitative features from. Subsequently, redundancy filtering and factor ...
Source: European Radiology - Category: Radiology Source Type: research
AbstractPurposeOur aim is to determine the impact of the size of ROI in detecting subcentimeter metastatic lymph nodes in patients with head and neck squamous cell carcinoma (HNSCC). Secondary aim is to determine the impact of the histopathologic grade of the primary cancer on the ADC value of the metastatic nodes.MethodsThe prospective study included 51 patients with histopathologically proven HNSCC at the primary site. Primary site includes oral cavity, oropharynx, larynx, and hypopharynx. ADC values of the lymph nodes were measured on ADC maps by placing two ROIs in the lymph nodes (0.2 cm2 in the center of the node and...
Source: Neuroradiology - Category: Radiology Source Type: research
Conclusions: These results indicate that sesamin suppresses the migration and invasion of HNSCC cells by regulating MMP-2 and is thus a potential antimetastatic agent for treating HNSCC.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Oral tongue squamous cell carcinomas (OTSCC) exhibit primary immune failure to control carcinogenesis demonstrated by the absence of an immune response to the development of nodal metastases or recurrent disease. Proinflammatory immune gene expression is counteracted by immunosuppressive signaling mediated by FOXP3 and PD ‐L1 expression. A gene signature was identified that was not prognostic in HNSCC but was significantly associated with survival in other cancers, demonstrating histotype‐dependent prognostic effects of immune regulation. AbstractWe investigated whether a unique immune response was instigated with the ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Abstract The head and neck squamous cell carcinoma (HNSCC) is an aggressive human malignancy diagnosed in more than 800 000 new cases worldwide, and mostly arises in the oral cavity, oropharynx, larynx, hypopharynx, and nasopharynx. The study presented here aimed to determine a possible association of rs11515 and rs3088440 gene polymorphisms in the CDKN2A gene (cyclin dependent kinase inhibitor 2A), as well as rs769412 and rs937283 in the MDM2 gene (murine double minute 2), with oral cavity cancer in a sample of Polish population; CDKN2A is crucial in regulating the cell cycle while MDM2 is an oncogene invo...
Source: Acta Biochim Pol - Category: Biochemistry Authors: Tags: Acta Biochim Pol Source Type: research
o Muto Ionna : Head and neck squamous cell carcinomas (HNSCCs) are a very heterogeneous group of malignancies arising from the upper aerodigestive tract. They show different clinical behaviors depending on their origin site and genetics. Several data support the existence of at least two genetically different types of HNSCC, one virus-related and the other alcohol and/or tobacco and oral trauma-related, which show both clinical and biological opposite features. In fact, human papillomavirus (HPV)-related HNSCCs, which are mainly located in the oropharynx, are characterized by better prognosis and response to ther...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
More News: Biology | Biomedical Science | Cancer | Cancer & Oncology | Carcinoma | Genetics | Head and Neck Cancer | HNSCC | Molecular Biology | Oral Cancer | Skin Cancer | Squamous Cell Carcinoma