Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Publication date: Available online 31 January 2020Source: Seminars in Cancer BiologyAuthor(s): Eunus S. Ali, Shazid Md. Sharker, Muhammad Torequl Islam, Ishaq N. Khan, Subrata Shaw, Md. Atiqur Rahman, Shaikh Jamal Uddin, Manik Chandra Shill, Shahnawaz Rehman, Niranjan Das, Saheem Ahmad, Jamil A. Shilpi, Swati Tripathi, Siddhartha Kumar Mishra, Mohammad S. MubarakAbstractNanotechnology is reshaping health care strategies and is expected to exert a tremendous impact in the coming years offering better healthcare facilities. It has led to not only therapeutic drug delivery feasibility but also to diagnostics. Materials in the size of nano range (1–100 mm) used in the design, fabrication, regulation, and application of therapeutic drugs or devices are classified as medical nanotechnology and nanopharmacology. Delivery of more complex molecules to the specific site of action as well as gene therapy has pushed forward the nanoparticle-based drug delivery to its maximum. Areas that benefit from nano-based drug delivery systems are cancer, diabetes, infectious diseases, neurodegenerative diseases, blood disorders and orthopedic-related ailments. Moreover, development of nanotherapeutics with multi-functionalities has a considerable potential to fill the gaps that exist in the present therapeutic domain. In cancer treatment, nanomedicines have superiority over current therapeutic practices as they can effectively deliver the drug to the affected tissues, thus reducing drug toxicit...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research