Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis
ConclusionsEighteen factors may increase the risk of carbapenem resistance inK. pneumoniae infection; eight factors may be associated with bothK. pneumoniae infections in general and CRKP in particular. The eight shared factors are likely to be ‘true’ risk factors for CRKP infection. Evaluation of risk factors in different situations may be helpful for empirical treatment and prevention of CRKP infections.
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Shengzhi Yang, Wenwen Deng, Shuliang Liu, Xiumei Yu, Ghulam Raza Mustafa, Shujuan Chen, Li He, Xiaolin Ao, Yong Yang, Kang Zhou, Bei Li, Xinfeng Han, Xuebin Xu, Likou Zou
In this study, 110 selected Aeromonas hydrophila isolates isolated from food, animals, and human clinical material from 2010 to 2015 were analyzed. Antimicrobial susceptibility testing was performed by the disk diffusion method, and polymerase chain reaction was conducted to investigate the virulence genes hemolysin (hlyA), cytotoxic enterotoxin (act), heat-labile cytotonic enterotoxin (alt), aerolysin (aerA), and DNase-nuclease (exu). At least 92.7% of the isolates had one of the investigated virulence genes. Twenty different virulence profiles among the isolates were recognized, and the five investigated virulence genes ...
Publication date: Available online 29 May 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Patrick Zemb, Peter Bergman, Carlos A. Camargo, Etienne Cavalier, Catherine Cormier, Marie Courbebaisse, Bruce Hollis, Salvatore Minisola, Stefan Pilz, Pawel Pludowski, François Schmitt, Mihnea Zdrenghea, Jean-Claude Souberbielle
This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period.
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Getuţa Nicolae Dopcea, Ioan Dopcea, Alina Elena Nanu, Camelia Filofteia Diguţă, Florentina Matei
ConclusionATP measurements can be used as a more objective approach to determine the level of environmental contamination in hospitals. Significant differences in ATP levels were found between hospitals and between countries. Also, substantial differences were found between different fomite groups. These findings offer potential targets for improvement of cleanliness in healthcare facilities.
H), Deutsche Gesellschaft für Pädiatrische Infektiologie e. V. (DGPI), Kommission Antiinfektiva, Resistenz und Therapie (Kommission ART) beim Robert Koch-Institut, Paul-Ehrlich-Gesellschaft für Chemotherapie e. V. (PEG), Robert Koch-Institut, Geschäftsstelle der Kommission ART Abstract Increased awareness of the rising antimicrobial resistance problem and impending loss of suitable treatment options for infectious diseases have changed patient care. Antimicrobial/antibiotic stewardship (ABS) activities aiming to optimize antimicrobial treatment were specified in international (WHO, ECDC) an...
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Tania Nawfal Dagher, Charbel Al-Bayssari, Selma Chabou, Sophie Baron, Linda Hadjadj, Seydina M. Diene, Eid Azar, Jean-Marc Rolain
Publication date: Available online 26 May 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Suchanda Dey, Mahendra Gaur, Rajesh Kumar Sahoo, Aradhana Das, Bhawana Jain, Sanghamitra Pati, Enketeswara Subudhi