Outcomes in Primary CNS Lymphoma Post BEAM Autologous Stem Cell Transplantation: A Single-Center Analysis.
Primary CNS lymphoma (PCNSL) is a variant of NHL, involving the brain, leptomeninges, spinal cord, and/or the eyes without any evidence of systemic disease. Optimal therapy in PCNSL is yet to be determined. High dose methotrexate (HD-MTx) forms the mainstay of treatment. Consolidation strategies include radiation, non-myeloablative chemotherapy or myeloablative chemotherapy followed by stem cell rescue (ASCT). Thiotepa-based conditioning is preferred for ASCT based on evidence of superiority over BEAM conditioning.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Arushi Khurana, Brian Patrick O'Neill, Thomas M. Habermann, Stephen Ansell, David J. Inwards, Luis F. Porrata, Ivana N. Micallef, Jonas Paludo, Jose Villasboas Bisneto, Patrick B. Johnston Tags: 352 Source Type: research
More News: Biology | Brain | Chemotherapy | Eyes | Hematology | Lymphoma | Methotrexate | Neurology | Primary CNS Lymphoma | Stem Cell Therapy | Stem Cells | Transplants