Outcomes in Primary CNS Lymphoma Post BEAM Autologous Stem Cell Transplantation: A Single-Center Analysis.

Primary CNS lymphoma (PCNSL) is a variant of NHL, involving the brain, leptomeninges, spinal cord, and/or the eyes without any evidence of systemic disease. Optimal therapy in PCNSL is yet to be determined. High dose methotrexate (HD-MTx) forms the mainstay of treatment. Consolidation strategies include radiation, non-myeloablative chemotherapy or myeloablative chemotherapy followed by stem cell rescue (ASCT). Thiotepa-based conditioning is preferred for ASCT based on evidence of superiority over BEAM conditioning.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 352 Source Type: research