From the Editor's Desk …

Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are closely associated, but it is not clear whether this is simply the result of them sharing the same risk factors, e.g. obesity, dyslipidaemia, insulin resistance and type 2 diabetes. Jiang et  al. propose a novel mechanism linking NAFLD and atherosclerosis. Using a series of advanced in vitro experiments, they show that steatotic hepatocytes release extracellular vesicles that contain microRNA-1. These extracellular vesicles induce a pro-inflammatory phenotype in endothelial cells tha t promotes atherogenic vessel activation.

Source: Journal of Hepatology - December 16, 2019 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research