Recombination of B- and T-cell epitope-rich loci from Aedes- and Culex-borne flaviviruses shapes Zika virus epidemiology.

Recombination of B- and T-cell epitope-rich loci from Aedes- and Culex-borne flaviviruses shapes Zika virus epidemiology. Antiviral Res. 2019 Dec 11;:104676 Authors: Gaunt MW, Gubler DJ, Pettersson JH, Kuno G, Wilder-Smith A, de Lamballerie X, Gould EA, Falconar AK Abstract Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Culex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic incongruence In relation to: 1) DENV T-cell maps experimentally identified ex vivo, 2) published B-cell epitope loci, and 3) CD8+ epitopes predicted in silico for mosquito-borne flaviviruses. Our findings demonstrate that the ZIKV proteome is a hybrid of Aedes-borne DENV proteins interspersed amongst Culex-borne flavivirus proteins derived through independent interspecies recombination events. These analyses infer that DENV-associated proteins in the ZIKV hybrid proteome generated immunodominant human B-cell responses, whereas ZIKV recombinant derived Culex-borne flavivirus-associated ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research

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Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vect...
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Science Infectious diseases Brighton UK news Source Type: news
Publication date: Available online 16 December 2019Source: Antiviral ResearchAuthor(s): Michael W. Gaunt, Duane J. Gubler, John H.-O. Pettersson, Goro Kuno, Annelies Wilder-Smith, Xavier de Lamballerie, Ernest A. Gould, Andrew K. FalconarAbstractSporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-bor...
Source: Antiviral Therapy - Category: Virology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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