Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2

Conclusions
mGluR2-Abs are a novel biomarker of paraneoplastic cerebellar ataxia. The potential pathogenic effect of the antibodies is not mediated by downregulation or internalization of neuronal surface mGluR2.

Source: Neurology Neuroimmunology and Neuroinflammation - December 10, 2019 Category: Neurology Authors: Ruiz-Garcia, R., Martinez-Hernandez, E., Joubert, B., Petit-Pedrol, M., Pajaron-Boix, E., Fernandez, V., Salais, L., del Pozo, M., Armangue, T., Sabater, L., Dalmau, J., Graus, F. Tags: Diagnostic test assessment, Autoimmune diseases, Clinical neurology examination, Gait disorders/ataxia, Paraneoplastic syndrome Article Source Type: research