Current use and development of fish vaccines in China

Publication date: Available online 9 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Qingchao Wang, Wei Ji, Zhen XuAbstractIn the past decades, the aquaculture industry made great progress in China, which contributes more than 70% yield of the world's farmed fish. Along with the rapid growth of fish production, increased emergence and outbreak of numbers of diseases pose harm to the aquaculture industry and food safety. From the efficient, safe, environmental and ethical aspects, vaccines is definitely the most appropriate and focused method to control different kinds of fish diseases. In China, researchers have done huge works on the fish vaccines, and so far six domestic aquatic vaccine products along with one imported aquatic vaccine have obtained the national veterinary medicine certificate. More critically, some new vaccines have also entered the field experiment stage and showed broad market prospects. In the present review, authors summarize seven aquatic vaccines, including the live vaccine against grass carp hemorrhagic disease, the inactivated vaccine against Aeromonas hydrophila sepsis in fish, the live vaccine against Edwardsiella tarda in turbot, the anti-idiotypic antibody vaccine against Vibrio alginolyticus, V. parahaemolyticus, and E. tarda in Japanese flounder, the cell-cultured inactivated vaccine against grass carp hemorrhagic disease, the inactivated vaccine against fish infectious spleen and kidney necrosis virus (ISKNV), and the geneticall...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research

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In this study, a whole-cell inactivated vaccine was obtained via sonication, and then single-walled carbon nanotubes (SWCNTs) was used to link to the bacterial lysate (BL) for a novel vaccine (SWCNTs-BL). A total of 400 fish were vaccinated with BL and SWCNTs-BL via immersion (5, 10 mg L−1) or injection (5, 10 μg/fish) before challenge with live A. hydrophila at the 28 days post immunization (d.p.i.). The results showed that the antibody titer, enzymatic activity, expression of some immune-related genes (especially IgM and TNF-α) and RPS of fish in the injection groups were significantly increased ...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 26 November 2019Source: Fish &Shellfish ImmunologyAuthor(s): Ronghua Wu, Junyu Shen, Xinlian Lai, Tao He, Yun LiAbstractThe disease outbreak caused by viral infection and bacterial pathogens has hampered the sustainable development of the gibel carp (Carassius auratus gibelio) industry, lack of monoclonal antibodies against serum immunoglobulin (Ig) of gibel carp has impeded the development of nonfatal immunoassays in detection of pathogen infection and understanding of fish immune response post vaccination. In the present study, serum Ig of gibel carp was purified by a combination of...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, the chemical structure of the vAh O-antigen was determined by chemical analysis, Smith degradation, mass spectrometry, and 2D proton and carbon nuclear magnetic resonance (NMR) spectroscopy and found to be unique among described bacterial O-antigens. The O-antigen consists of hexasaccharide repeating units featuring a 4)-α-l-Fucp-(1-3)-β-d-GlcpNAc-(1-4)-α-l-Fucp-(1-4)-β-d-Glcp-(1- backbone, substituted with single residue side chains of α-d-Glcp and α-d-Quip3NAc linked to O-3 of the two fucose residues. The polysaccharide is partially O-acetylated on O-6 of the 4-substituted...
Source: Carbohydrate Research - Category: Genetics & Stem Cells Authors: Tags: Carbohydr Res Source Type: research
Channel catfish farming dominates the aquaculture industry in the United States. However, epidemic outbreaks of motile Aeromonas septicemia (MAS), caused by virulent Aeromonas hydrophila (vAh), have become a prominent problem in the catfish industry. Although vaccination is an effective preventive method, there is no vaccine available against MAS. Recombinant proteins could induce protective immunity. Thus, in this work, vAh ATPase protein was expressed, and its protective capability was evaluated in catfish. The purified recombinant ATPase protein was injected into catfish, followed by experimental infection with A. hydro...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, the genetic parameters of resistance to Aeromonas hydrophila were reported for the first time in the bighead catfish, Clarias macrocephalus Günther, 1864 which is an important parental species for the production of the commercially important hybrid C. macrocephalus × C. gariepinus. The analyses were performed on 736 data records obtained from 74 full-sib families (31 half-sib families) produced by factorial mating design. The results showed that the heritability of survival rate after disease (Aeromonas hydrophila) challenge (intraperitoneal injection with 0.1 ml containing 1 × 106...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Lixing Huang1, Lingmin Zhao1, Wenjia Liu1, Xiaojin Xu1, Yongquan Su2, Yingxue Qin1 and Qingpi Yan1,2* 1Key Laboratory of Healthy Mariculture for the East China Sea, Fisheries College, Jimei University, Ministry of Agriculture, Xiamen, China 2State Key Laboratory of Large Yellow Croaker Breeding, Ningde, China Pseudomonas plecoglossicida is a temperature-dependent opportunistic pathogen which is associated with a variety of diseases in fish. During the development of “white nodules” disease, the expression of htpG in P. plecoglossicida was found to be significantly up-regulated at its virulent tempera...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, while dietary tryptophan supplementation might have harmful effects in control fish, it might prove to be a promising strategy to overcome chronic stress-induced disease susceptibility in farmed Senegalese sole. Introduction Every physiological response (e.g., metabolism, mineral balance, reproduction, growth, and immune function) is at least partly regulated by neuroendocrine mechanisms, which, in teleosts, are orchestrated by the hypothalamus-pituitary-interrenal (HPI) axis. Neuroendocrine signals are released upon stimulation of HPI axis and responses are highly different within each context. In f...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions In conclusion, this investigation indicated that citral attenuated multiple virulence factors of V. parahaemolyticus, including QS, motility, biofilm formation, the adhesion to Caco-2 cells, and repressed the expression of genes related to flagella (polar and lateral), biofilm and T3SS1 effectors, virulence regulators (luxS, aphA and toxR), and AMP resistance. The results obtained in this work demonstrate the inhibitory effect of citral on virulence factors of V. parahaemolyticus. However, the data reported in this study only demonstrate the anti-virulence effect of citral in vitro. Further research is needed ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion This study revealed that Enterococcus species with biofilm potentials and extracellular virulence properties extensively occur in retail RTE shrimps. A significant number of isolated strains are resistant to antibiotics and harbor resistant and virulent genes, denoting a significant route of resistance and virulence dissemination to bacteria in humans. There is an inadequate understanding of the intricacies of antibiotic-resistant enterococci of food origin that belong to enterococci aside from E. faecium and E. faecalis. Findings from this study reveal detailed antibiotic resistance of E. durans, E. casselifla...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Raquel Xavier1, Renata Mazzei2, Marcos Pérez-Losada1,3, Daniela Rosado1, Joana L. Santos1, Ana Veríssimo1 and Marta C. Soares1* 1CIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos da Universidade do Porto, Porto, Portugal 2Laboratoire d’Eco-Ethologie, Institut de Biologie, Université de Neuchâtel, Neuchâtel, Switzerland 3Computational Biology Institute, Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, Ashburn, VA, United States The broadstripe cleaning goby...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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