The role of Bax in the apoptosis of Leishmania-infected macrophages

ConclusionWith regard to the supportive role of bax in apoptosis and the preventive role of Leishmania in its function, it seems that expression of bax gene in parasite by technologies like transgenic or down regulating of anti-apoptotic molecule Bcl-2 by miRNA could be prompted the apoptosis process of infected-macrophages and inhibited extensive spread of Leishmania and the resulting lesions.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research