The effect of polyvalent mechanical bacterial lysate on the reduction of nasal Staphylococcus aureus carriage in children with pollen allergic rhinitis

Conclusion: PMBL improves the clinical course of SAR in school-aged children. However, this effect has not been shown to be related to the ability of PMBL to decolonize MRSA from the nose.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research

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ConclusionsThis large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Fang Yi, Lina Han, Baojuan Liu, Xu Zhang, Yongxin Xue, Wei Luo, Qiaoli Chen, Kefang LaiAbstractBackgroundNot all patients with cough variant asthma (CVA) show responsiveness to bronchodilators (RB) in clinic. Whether there are specific clinical and pathophysiological features can indicate RB in patients with CVA needs further investigation. Thus, we aimed to investigate the RB in patients with CVA and associated factors.MethodsForty-two CVA patients were randomized in a 2:1 ratio to receive oral bambuterol hydrochl...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: 20 February 2020Source: Cell, Volume 180, Issue 4Author(s): Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Wengong Jin, Andres Cubillos-Ruiz, Nina M. Donghia, Craig R. MacNair, Shawn French, Lindsey A. Carfrae, Zohar Bloom-Ackerman, Victoria M. Tran, Anush Chiappino-Pepe, Ahmed H. Badran, Ian W. Andrews, Emma J. Chory, George M. Church, Eric D. Brown, Tommi S. Jaakkola, Regina Barzilay, James J. CollinsSummaryDue to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting mole...
Source: Cell - Category: Cytology Source Type: research
Even if children ultimately get caught up on their vaccines after early delays, they remain susceptible to vaccine-preventable diseases for longer right when they're most vulnerable to complications.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics News Source Type: news
Authors: Akter S, Huq MA Abstract The present study highlights the biological synthesis of silver nanoparticles (AgNPs) using Sphingobium sp. MAH-11 and also their antibacterial mechanisms against drug-resistant pathogenic microorganisms. The nanoparticle synthesis method used in this study was reliable, facile, rapid, cost-effective and ecofriendly. The AgNPs exhibited the highest absorbance at 423 nm. The TEM image expressed spherical shape of AgNPs and the size of synthesized AgNPs was 7-22 nm. The selected area diffraction (SAED) pattern and XRD spectrum revealed the crystalline structure of AgNPs...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
This study leads to a possibility for the development of therapeutics in aquaculture biotechnology.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, we found that EPI effectively suppressed LTA-induced production of proinflammatory factors in macrophages. Mechanistically, EPI attenuated LTA-induced inflammation by inhibiting Toll-like receptor (TLR) 2 internalization and subsequent downstream signaling (reactive oxygen species, Akt, p38 and Nuclear factor κB). However, protein abundance of TLR2 was not altered by EPI or LTA. Taken together, our findings reveal for the first time that EPI possesses inhibitory activity toward LTA-induced inflammation in macrophages.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 20 February 2020Source: Carbohydrate PolymersAuthor(s): Shivayogi S. Narasagoudr, Veena G. Hegde, Vinayak N. Vanjeri, Ravindra B. Chougale, Saraswati P. MastiAbstractEthyl vanillin (EV) incorporated chitosan (CS)/poly(vinyl alcohol)(PVA) blend films of various ratios (1:3, 1:1 and 3:1) were prepared by solvent casting technique. The effect of EV on the mechanical, structural, barrier, optical, food compatibility and antibacterial properties of the CS/PVA films were investigated. Mechanical properties showed that addition of EV increased tensile strength of CPEV-1, CPEV-2 and CPEV-3 films ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
The Houston ENT&Allergy Clinic not only slashed its no-show rates, but also increased its referral conversion by 35%, which translated to an additional $500,000 in annual revenue.
Source: Healthcare ITNews Videos - Category: Information Technology Tags: Patient Engagement Telehealth Source Type: video
ConclusionsFitness tracker sleep efficiency and wake counts demonstrate clinical utility as predictive of asthma-specific night-time wakening and daily FEV1. Fitness tracker sleep data demonstrated predictive capability for daily asthma outcomes.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
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