Burden of comorbidities in patients with OSA and COPD-OSA overlap syndrome
Introduction: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary (COPD), are usually accompanied by several comorbidities. Aim of the study was to assess the prevalence of comorbidities in OSA and COPD-OSA overlap syndrome (OS) patients and to explore differences between these two groups.Methods: Included were consecutive OS (n=163, 138 males, AHI>5/h and FEV1/FVC5/h and FEV1/FVC>0.7), matched in terms of gender, age, BMI, and smoking history, diagnosed with polysomnography and pulmonary function testing.Results: As mentioned, the two groups were matched in age (p=0.221), BMI (p=0.496) and neck circumference (p=0.922). No difference was observed in ESS values (p=0.988), AHI (p=0.346), ODI (p=0.668) and minimum sleep oxyhaemoglobin saturation (p=0.100). Compared to OSA patients, OS patients had lower average sleep oxyhaemoglobin (p=0.008), higher sleep time with oxygen saturation
Publication date: November–December 2020Source: Heart &Lung, Volume 49, Issue 6Author(s): Linda Clements, Susan K. Frazier, Debra K. Moser, Terry A. Lennie, Misook L. Chung
CONCLUSIONS: Elevated plasma TMAO level in patients with heart failure is associated with poorer prognoses. This association is only partially mediated by renal dysfunction. PMID: 32959366 [PubMed - as supplied by publisher]
Publication date: Available online 21 September 2020Source: European Journal of RadiologyAuthor(s): Ana I. Garcia Diez, David Fuster, Laura Morata, Ferran Torres, Ruben Garcia, Daniel Poggio, Santiago Sotes, Montserrat Del Amo, Jaime Isern-Kebschull, Jaume Pomes, Alex Soriano, Laura Brugnara, Xavier Tomas
Publication date: 1 January 2021Source: Personality and Individual Differences, Volume 168Author(s): Feizhong Zheng, Wenting Wu, Lijing Wang, Arlette J. Ngoubene-Atioky, Li Chen
CONCLUSION: In a NHP ARS model, sargramostim administered starting at 48 h post-radiation was effective to improve survival, while beneficial hematological effects were observed with sargramostim initiated up to 120 h post exposure. PMID: 32960660 [PubMed - as supplied by publisher]
Abstract Postmenopausal osteoporosis causes severe loss of bone quantity and quality in limb bone but has a lesser effect on jaw bone. Thus, the objective of this study was to examine whether ovariectomy (OVX) and mastication alter the regional variation of jaw bone characteristics. Sprague-Dawley female rats (6 months) were given a bilateral OVX or a sham operation (SHAM) (n = 10 for each group). After 2 months post-OVX, the hemi-mandible from each rat was dissected. A micro-computed tomography based mean, standard deviation (SD), the lower and upper 5th percentile (Low5 and High5) values of tissue mine...
Abstract The optic nerve sheath (ONS) is biomechanically important. It is acted on by tension due to ocular movements, and by fluid shifts and/or alterations in intracranial pressure (ICP) in human disease, specifically in pathologies leading to intracranial hypertension. It has also been hypothesized that the ONS is acted on by altered ICP in astronauts exposed chronically to microgravity. However, a non-invasive method to quantify ONS biomechanical properties is not presently available; knowledge of such properties is desirable to allow characterization of the biomechanical forces exerted on the optic nerve head...
Publication date: Available online 21 September 2020Source: Pregnancy HypertensionAuthor(s): Kim J.C. Verschueren, Rubinah R. Paidin, Annabel Broekhuis, Olivier S.S. Ramkhelawan, Lachmi R. Kodan, Humphrey H.H. Kanhai, Joyce L. Browne, Kitty W.M. Bloemenkamp, Marcus J. Rijken
CONCLUSIONS: Under a real-life clinical practice setting, SSTS provides effective pain management and is easy to use for patients and nurses. PMID: 32959632 [PubMed - as supplied by publisher]
In 2019, before the pandemic hit, nearly 1 in 5 adults had depression and nearly 1 in 6 had anxiety, with dramatic increases seen in 2020.Medscape Medical News
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