Age of acquisition effects differ across linguistic domains in sign language: EEG evidence.

We examined neural responses of a group of Deaf signers who received access to signed input at varying ages to three linguistic phenomena at the levels of classifier signs, syntactic structure, and information structure. The amplitude of the N400 response to the marked word order condition negatively correlated with the age of acquisition for syntax and information structure, indicating increased cognitive load in these conditions. Additionally, the combination of behavioral and neural data suggested that late learners preferentially relied on classifiers over word order for meaning extraction. This suggests that late acquisition of sign language significantly increases cognitive load during analysis of syntax and information structure, but not word-level meaning. PMID: 31698097 [PubMed - as supplied by publisher]
Source: Brain and Language - Category: Neurology Authors: Tags: Brain Lang Source Type: research

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Auditory verbal hallucinations (AVHs) are considered as hallmark symptoms of psychosis, more specifically of schizophrenia. A substantial body of evidence indicates that AVHs can be attributed to a disorganization of overall speech capacity in psychotic subjects. AVHs are associated with activation of cortical areas of the brain that are related to speech production and perception; “voices” in deaf patients seem to be about the message rather than the sound of it; the content of AVHs is often related to that of delusional ideas; the internal or external location of AVHs makes little diagnostic difference; AVHs ...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Brief Report Source Type: research
Abstract Auditory neuropathy spectrum disorder (ANSD), also called auditory neuropathy (AN), is a unique type of prelingual hearing impairment. Up to 10% of deaf infants and children are affected by this disease. Mutation of the OTOF gene which encodes otoferlin is the common cause of congenital nonsyndromic ANSD. To date, over 110 mutations have been identified in the OTOF gene according to the Human Gene Mutation Database (HGMD). Here, next-generation sequencing (NGS) revealed that the compound heterozygous mutations c.4748G>A/c.2523+1G>T and c.5248G>C/c.5098G>C of the OTOF gene were present in two C...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
CONCLUSIONS: Patients with CHARGE syndrome have a high prevalence of characteristic cerebellar heterotopias and disorganized foliation and abnormal cerebellar morphology, thereby expanding the phenotype of cerebellar dysgenesis in this syndrome.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: PEDIATRICS Source Type: research
Nuclear modifier genes have been proposed to modify the phenotypic expression of mitochondrial DNA mutations. Using a targeted exome-sequencing approach, here we found that the p.191Gly>Val mutation in mitochondrial tyrosyl-tRNA synthetase 2 (YARS2) interacts with the tRNASer(UCN) 7511A>G mutation in causing deafness. Strikingly, members of a Chinese family bearing both the YARS2 p.191Gly>Val and m.7511A>G mutations displayed much higher penetrance of deafness than those pedigrees carrying only the m.7511A>G mutation. The m.7511A>G mutation changed the A4:U69 base-pairing to G4:U69 pairing at the aminoacy...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: RNA Source Type: research
Conclusion: The reduction of tinnitus in the current ABI subject may be attributable to partial peripheral reafferentation-induced deactivation of the parahippocampus-based tinnitus generator as well as the salience network. Further validation is required by the use of a follow-up study with a larger number of subjects.
Source: Otology and Neurotology - Category: ENT & OMF Tags: AUDIOLOGY Source Type: research
Conclusion: The etiology of vestibular loss appears to have a profound impact on sensitivity of vestibular afferents in distinction to cochlear afferents. If this dichotomy is common, it may limit the application of vestibular implants to diagnoses with preserved sensitivity of vestibular afferents. We speculate it is due to differences in topographic organization of Scarpa's versus the spiral ganglion. In two subjects, the second-generation device can produce higher velocity eye movements than seen in the four subjects receiving the first-generation device.
Source: Otology and Neurotology - Category: ENT & OMF Tags: PROSTHETIC DEVICES Source Type: research
Conditions:   Migraine;   Vestibular Migraine;   Vestibular Schwannoma;   Motion Sickness;   Dizziness;   Vestibular Disorder Interventions:   Behavioral: Temporal Binding Adaptation - TBW training;   Behavioral: Temporal Binding Adaptation - PSS training;   Behavioral: Temporal Binding Adaptation - PSS adaptation with VI stimulation;   Behavioral: Chronic Motion-modulated Stimulation Sponsors:   Massachusetts Eye and Ear Infirmary;   National Institute on Deafness and Other Communication Disorders (NIDCD); &n...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 10 December 2019Source: NeuroImageAuthor(s): Daniel Smieja, Benjamin T. Dunkley, Blake C. Papsin, Vijayalakshmi Easwar, Hiroshi Yamazaki, Michael Deighton, Karen A. GordonAbstractDespite early bilateral cochlear implantation, children with congenital deafness do not develop accurate spatial hearing; we thus asked whether auditory brain networks are disrupted in these children. EEG responses were evoked unilaterally and bilaterally in 13 children with normal hearing and 16 children receiving bilateral cochlear implants simultaneously. Active cortical areas were estimated by the Time Restri...
Source: NeuroImage - Category: Neuroscience Source Type: research
ACTIVE MIDDLE EAR VIBRANT SOUNDBRIDGE SOUND IMPLANT. Acta Clin Croat. 2019 Jun;58(2):348-353 Authors: Pegan A, Ries M, Ajduk J, Bedeković V, Ivkić M, Trotić R Abstract The Vibrant Soundbridge represents a new approach to hearing improvement in the form of active implantable middle ear hearing device. Unlike conventional acoustic hearing aids, which increase the volume of sound that goes to the eardrum, the Vibrant Soundbridge bypasses the ear canal and eardrum by directly vibrating the small bones in the middle ear. Because of its design, no portion of the device is placed in the ear canal itself. T...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
This study further highlights the challenges of identifying disease-causing variants for highly heterogeneous disorders and reports the identification of three novel and four previously reported variants in seven known deafness genes.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Communication Source Type: research
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