Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

Adverse childhood experiences (ACEs) may be referred to by other terms (e.g., early life adversity or stress and childhood trauma) and have a lifelong impact on mental and physical health. For example, childhood trauma has been associated with posttraumatic stress disorder (PTSD), anxiety, depression, bipolar disorder, diabetes, and cardiovascular disease. The heritability of ACE-related phenotypes such as PTSD, depression, and resilience is low to moderate, and, moreover, is very variable for a given phenotype, which implies that gene by environment interactions (such as through epigenetic modifications) may be involved in the onset of these phenotypes. Currently, there is increasing interest in the investigation of epigenetic contributions to ACE-induced differential health outcomes. Although there are a number of studies in this field, there are still research gaps. In this review, the basic concepts of epigenetic modifications (such as methylation) and the function of the hypothalamic-pituitary-adrenal (HPA) axis in the stress response are outlined. Examples of specific genes undergoing methylation in association with ACE-induced differential health outcomes are provided. Limitations in this field, e.g., uncertain clinical diagnosis, conceptual inconsistencies, and technical drawbacks, are reviewed, with suggestions for advances using new technologies and novel research directions. We thereby provide a platform on which the field of ACE-induced phenotypes in mental health...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: January 2020Source: Brain, Behavior, and Immunity, Volume 83Author(s): Elisa Brietzke, Linda Booij, Andrea Wieck, Alessandro Ricci, Claudio N. Soares, Nasreen Roberts, Sarosh Khalid-Khan
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
“The hospital room was as cold as dead skin, the hallway crowded with lost souls and reeking of illness.” ― Raquel Cepeda,“Bird of Paradise: How I Became Latina” Once upon a time, I met a young lady who wanted to be a doctor. I could see the naked determination and resolve in her eyes. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Diabetes Hospital-Based Medicine Source Type: blogs
Conclusions: These findings suggest that among MDD patients, early experiences of emotional and physical abuse and neglect is associated with difficulties in describing feelings in adulthood. PMID: 31808358 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Schulte C, Zeller T Abstract Cardiovascular (CV) risk assessment is based on the utilization of risk scores, enabling clinicians to estimate an individual's risk to develop CV pathologies and events. Such risk scores comprise classic CV risk factors such as smoking, diabetes, hypertension, and blood cholesterol levels. Recently, other CV biomarkers such as cardiac troponins have been suggested and evaluated as alternative biomarkers not only in the acute diagnostic setting of myocardial infarction, but also as markers for risk stratification in the general population. In this review, we summarize the curre...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Many patients with cognitive impairment have anxiety or depression, but standard treatments are difficult for people with memory issues.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Mental Health and Disorders Depression (Mental) Alzheimer ' s Disease Memory Dementia Psychology and Psychologists Elderly Weill Cornell Medicine your-feed-healthcare Source Type: news
Conclusion: Our results indicate similar prevalence rates of comorbid psychiatric symptoms to studies carried out in the Middle East and North Africa (MENA) region and relatively high attendance and referral rates to psychiatric services.Implications: The results shed light on the clinical profile of patients in this region and support the need for integrated collaborative medical services. Moreover, findings have important implications for health care policies pertaining to resource distribution and funding.IntroductionMedical care has traditionally been dominated by a separation between disciplines catering to physiologi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Gamification is gaining recognition as a powerful tool for contexts far removed from gaming itself, and the approach has been used for applications as varied as advertising, to recruiting, to rewards programs. Litesprite hopes to expand the gaming ap...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Net News Pediatrics Psychiatry Source Type: blogs
“I have chosen a surreal art approach to represent my invisible disability, due to the surreal nature of mental illness,” tattoo artist Lindsay Carter expressed in a statement. Carter’s image ― featured on the right, above ― shows a bird whose head is a cage with a giant eyeball protruding from the dreamlike vision.  “As long as I’ve been consciously aware, I’ve been diagnosed with generalized anxiety disorder and major depressive disorder,” she continued. “Severe episodes can happen for no apparent reason and at that point I cannot help nor snap out of the...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This study compared the next-day residual effects of acute and steady-state nighttime doses of flibanserin (100mg/day and 200mg/day) on simulated driving performance and cognition in healthy female subjects. Objective: To test for negative effects on measures of next-day simulated driving performance and cognitive testing Methods: Healthy, premenopausal females (18–-50 years of age) were randomized to flibanserin (100mg or 200mg), zopiclone (7.5mg), or matching placebos the evening prior to testing in a double-blind, placebo-controlled, Latin-square design, with four-way, four-period crossover (n=83). Zopiclone was s...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Genetics Supplements Trial Methodology CNS Summit poster presentation abstracts Source Type: research
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