Stem cell-derived extracellular vesicles for renal repair: Do cardiovascular comorbidities matter?

Stem cell-derived extracellular vesicles for renal repair: Do cardiovascular comorbidities matter?
Am J Physiol Renal Physiol. 2019 Oct 21;:
Authors: Eirin A, Lerman LO
Abstract
Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease (CKD). However, individuals with CKD often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells (MSCs) and MSC-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.
PMID: 31630544 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 20, 2019 Category: Urology & Nephrology Authors: Eirin A, Lerman LO Tags: Am J Physiol Renal Physiol Source Type: research