Determination of N, N-diethyl-3-methylbenzamide and ethyl-butyl-acetylaminopropionate in Insect repellent using near infrared spectroscopy and multivariate calibration

Publication date: Available online 18 October 2019Source: Microchemical JournalAuthor(s): Welma T.S. Vilar, Mayara F. Barbosa, Licarion Pinto, Mário César Ugulino de Araújo, Márcio José Coelho PontesABSTRACTAedes aegypti mosquitoes are vectors of diseases such as dengue, chikungunya, zika and yellow fever. With the increase in the incidence of these diseases the population has resorted to the use of repellents searching to protect themselves from mosquito attack. The Brazilian market offers a wide variety of products with different active principles in varying levels of concentration, times of action and different prices, where DEET (N, N-diethyl-3-methylbenzamide) and IR3535 (ethyl-butyl-acetylaminopropionate) based repellents are suitable for use around adults and children, respectively. The action time of these repellents depends, among other factors, on the concentration of their active ingredients. Chromatographic methods are recommended to quantify these compounds in different samples. However, these methods require long analysis time, and use reagents that are expensive and generate toxic waste. Near Infrared Spectroscopy (NIRS) has been applied in several areas of research on this subject and is characterized by its rapid, low cost, non-destructive characteristics no sample treatment is required. The present work proposes the development of a methodology based on NIR spectroscopy and multivariate calibration for determination of DEET and IR 3535 in samples from c...
Source: Microchemical Journal - Category: Chemistry Source Type: research