A case of Hashimoto's thyroiditis with multiple drug resistance and high expression of efflux transporters.

CONCLUSIONS: High expression and accelerated efflux transporter activity of ABCG2/BCRP in the small intestine are expected to contribute to the ineffectiveness of orally administered intact tablets in cases with treatment-resistant Hashimoto's thyroiditis, and crushed tablets can be more effective for some of these patients.
PMID: 31614366 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2019 Category: Endocrinology Authors: Yoshida T, Nakayama A, Tamura A, Higuchi S, Sakuma I, Nagano H, Felizola SJA, Hashimoto N, Takemoto M, Tatsuno I, Koide H, Yokote K, Tanaka T Tags: J Clin Endocrinol Metab Source Type: research