Metformin Lactic Acidosis: should we still be afraid?
Metformin, the first choice drug for type 2 diabetes treatment in all stages of therapy, and one of the most widely prescribed anti-hyperglycemic agent worldwide, represents a rare example of an old drug which continues to display new beneficial effects in various fields. However, lactic acidosis (LA) persists as a serious adverse effect. LA incidence is low and is not necessarily determined by the administration of metformin. Unfortunately, the concern for this complication has negatively affected the drug use, particularly in chronic kidney disease, which may impair drug excretion, and in congestive heart failure and chronic liver disease, which may promote lactate accumulation.
Conclusion A high prevalence of malnutrition and of other risk factors for cardiovascular disease were observed. Such factors included diabetes Mellitus, smoking and former smoker conditions and were associated with malnutrition. Inaddition, it was found that malnourished individuals were more likely to develop cardiovascular disease within 10 years.RESUMO Objetivo Verificar associa ção entre estado nutricional e fatores de riscos cardiovasculares tradicionais e não tradicionais em pacientes em hemodiálise. Métodos Estudo transversal com 132 pacientes maiores de 18 anos em hemodiál...
This study was to screen strains which had effects on insulin resistance in vitro and explore the possible mechanism. These strains were tested the ability of colonization, hormone release, lipid accumulation, glucose uptake and immunomodulatory. Three strains of Lactobacillus paracasei 1F-20, Lactobacillus fermentum F40-4 and Bifidobacterium animalis subsp. lactis F1-7 led to results as follows: (1) survived in the harsh conditions. (2) increased the hormone release of glucagon-like peptide 1(GLP-1), peptide YY (PYY) and up-regulated genes expression of proglucagon gene (GCG), PYY; (3) decreased lipid accumulation, down-r...
In honor of Veterans Day in the USA, DiabetesMine looks at dangers military veterans with diabetes may be facing at the VA.
ConclusionQHD inhibits LPS gut-leakage in NASH, which is associated with downregulation of intestinal MAPK pathway.Graphical abstract
A1c was reduced significantly more with oral semaglutide versus empagliflozin in a comparison of the type 2 diabetes drugs, but the former still lacks evidence of CV efficacy.Medscape Medical News
Investigational drug impacts hunger and reduces weight in two small, preliminary trials in patients with obesity caused by two rare genetic mutations; agent may have wider uses, says an expert.Medscape Medical News
The American population is getting older and sicker. More Americans are facing life-threatening illness when approaching end of life. Palliative care has grown to meet the complex needs of this population. And yet, according to a 2017 article in the journal Palliative Care, many people living with a chronic life-threatening illness either do not receive any palliative care, or receive services only in the last phase of their illness. The National Consensus Project Clinical Practice Guidelines for Quality Palliative Care also addressed this issue, stating that a goal of their recently updated guidelines is “to improve...
Admissions have reached record levels in England, rising from 65,025 in 2013/14 to 86,474 in 2018/19, reflecting increasing numbers of people living with heart failure in UK (~920,000 people), which is placing greater burden on health service than 4 most common cancers combined.
A unique photo exhibit highlights the additional struggles homeless people with diabetes face.
Today, metformin is considered to be the first-choice drug and is considered the gold standard for most people with type 2 diabetes. Metformin is the most commonly used diabetic medication used worldwide. Metformin use in patients with congestive heart failure, moderate chronic kidney disease, or chronic liver disease with hepatic impairment is associated with improvements in mortality. Research has shown that metformin also has a protective effect on endothelium by decreasing endothelial vascular reactivity.