Chemokine alterations in the postmortem brains of suicide completers

We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q 
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research

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It is well known that only a small proportion of the human genome code for proteins; the rest belong to the family of RNAs that do not code for protein and are known as non-coding RNAs (ncRNAs). ncRNAs are further divided into two subclasses based on size: 1) long non-coding RNAs (lncRNAs;>200 nucleotides) and 2) small RNAs (
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractEmergency psychiatry has the main role of resolving suicidal behavior and aggression. These severe psychiatric symptoms can be found in many psychiatric disorders such as schizophrenia, bipolar disorder, major depression, personality disorders, cognitive disorders, intellectual disability and substance abuse. Although indications for the use of antipsychotics are limited to a specific group of diseases, they are frequently used as rescue medication in high-risk or nonresponsive cases. Clozapine, the gold standard for TRS (treatment resistant schizophrenia) is effective in controlling aggression. The aim of the rese...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: SA and NSSI are one of the main reasons for child and adolescent admittance to psychiatric services in the PED and are associated with psychiatric comorbidities. An appropriate risk assessment for suicidality and self-injury and proper management and referral to mental health services at the PED are of the utmost importance. PMID: 32830466 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Vascular aging is an important contribution to neurodegeneration. The brain is an energy-hungry organ, and reductions in blood flow with age have a negative impact on brain tissue. These reductions can occur for obvious reasons such as the weakening of the heart in cases of heart failure, but there are other, more subtle processes at work to reduce the delivery of nutrients to the brain, such as the progressive stiffening of blood vessels and reductions in capillary density. Researchers here note that greater excess fat tissue, as measured by body mass index, correlates with reduced blood flow in the brain. It is plausible...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: Three in 10 Medicare beneficiaries had a preexisting mental illness diagnosis, which was strongly associated with worse postoperative outcomes, as well as suicide risk. Surgeons need to optimize mental health assessment and services in the preoperative setting to improve outcomes for this vulnerable population.
  From lobotomies to pharmaceutical advertising to forced treatment, let’s discuss some of the more taboo topics in the history of psychiatry. While some of these approaches are obviously terrible (especially in hindsight) others are in the gray area. Should pharmaceutical companies be able to advertise directly to the patient? Is it OK to force psychiatric treatment in certain cases? What do you think? Tune in to today’s Not Crazy episode for a great discussion on the more controversial topics in the field of psychiatry. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Re...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Psychiatry Treatment Source Type: blogs
  What does psychosis feel like? What’s the difference between a delusion that demons exist and a religious belief of the same? In today’s show, Gabe and Lisa recall Gabe’s real-life psychotic episodes and discuss all the pain and stress surrounding psychosis. Join us as Gabe shares how it felt when there were demons under his bed and when the window washers were watching his every move. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews!  About The Not Crazy podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar General Not Crazy Podcast Schizophrenia Source Type: blogs
Rates of psychosis are more strongly influenced by ethnicity and socioeconomic status than any other mental health condition. In this episode of Inside Schizophrenia host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard discuss the impact of schizophrenia in minority communities. Guest Sakinah “The Muslim Hippie” joins to share her experiences in mental health care. Highlights of “Impact of Schizophrenia in Minority Communities [01:00] The realization [02:08] Sociology definition of the word minority [04:30] The stats of mental health and minorities [09:00] Diagnosing differences ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Mental Health and Wellness Podcast Psychiatry Psychology Racism Stigma brain Mental Disorder Mental Illness Minorities Minority Populations Source Type: blogs
Conclusion, do not visit cardiologists. They will give you heart attacks. No, that’s ridiculous. It’s so mind blowing that anyone even said this, right? It’s just ugh. Obviously, people who are extremely sick and who are at risk of killing themselves get psychiatric care. No kidding. So, yeah, this is, in fact, very dangerous. Gabe: The word bullshit is not big enough. This is the literal equivalent of me saying that I looked at fifty thousand people who went to the hospital in the last year. And you were much more likely to die if you had a hospital admission. Now, I’m talking physical health now. ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Mental Health and Wellness Not Crazy Podcast Psychiatry Treatment Source Type: blogs
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