Molecular markers of regulatory T cells and their importance in anticancer chemotherapy - A comprehensive review.

Molecular markers of regulatory T cells and their importance in anticancer chemotherapy - A comprehensive review. Curr Med Chem. 2019 Oct 04;: Authors: Kaboli PJ, Zhang L, Xiang S, Shen J, Li M, Zhao Y, Wu X, Zhao Q, Zhang H, Lin L, Yin J, Wu Y, Wan L, Yi T, Li X, Cho CH, Li J, Xiao Z, Wen Q Abstract Immunological principles based on Treg cell self-stabilization and the discovery that tumors are capable of evading the body's defense mechanism have led to more effective immuno-oncology therapies. Hence, next generation immunotherapy can only be effective if researchers have an in-depth understanding of the function and regulation of Treg cells in antitumor immunity combined with the discovery of new immunity targets. This can enhance clinical efficacy of future and novel therapies and reduces any adverse reactions arising from the latter. This review of the literature discusses tumor treatment strategies using regulatory T (Treg) cell therapy in a tumor microenvironment (TME). It also discusses factors affecting TME instability as well as relevant treatments to prevent future immune disorders. In order to prognosticate the risk and adverse effects of key target inhibitors, we also reviewed and analyzed the Cancer Genome Atlas (namely regulatory T cells CTLA-4, FoxP3, CD25, and PD-1) derived from ten common cancers and compared those between cancer patients and healthy people. It is prognosticated PD-1 inhibitors are risky and their ad...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research