Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/ α-synuclein axis in atrazine-induced Parkinson's disease by peripheral blood and brain microRNA profiling.

In this study, we carried out miRNA profiling of peripheral blood and brain tissue in a rat model of PD in order to identify factors that mediate PD pathogenesis. The miRNAmiR-7 is known to cause the downregulation of α-synuclein (α-syn), which is linked to the neuropathology of PD. Here we found that miR-7 was upregulated in brain tissue but downregulated in peripheral blood of rats with ATR-induced PD. We also found that miR-7 regulates the expression of brain-derived neurotrophic factor (BDNF) through an auto regulatory mechanism. These findings indicate that miRNA-7 regulates the BDNF/α-syn axis in the early stages of PD and can serve as a biomarker or therapeutic target for disease treatment. PMID: 31185338 [PubMed - indexed for MEDLINE]
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research