Baclofen-induced dyshidrosiform bullous pemphigoid in a paraplegic patient complicated with methicillin-resistant Staphylococcus aureus (mrsa) and urinary infection

Bullous pemphigoid (BP) is an autoimmune disorder which is usually chronic, with blistering that predominantly affects the skin and occasionally the mucosa, and which includes several different types. One of them is a very rare dyshidrosiform type which is localized on the hands and feet with small or large blisters on the palmoplantar surfaces. BP resulting from a drug reaction is a relatively rare occurrence, and so far more than 50 different medications have been identified as triggers. The aim of this article was to present the case of a paraplegic patient who developed this rare dyshidrosiform type of BP while he was being neurologically treated with baclofen. In spite of therapy with systemic and topical corticosteroids and other measures, successful treatment was achieved only after eliminating baclofen from the patient ’s regimen. His general state of health was seriously endangered due to nasal and skin methicillin-resistantStaphylococcus aureus (MRSA), urinary infection, and oral mycosis (soor), and he was at high risk of sepsis and a fatal outcome. Through our efforts, however, we managed to achieve an excellent outcome. According to our knowledge, this was the first case of baclofen-induced dyshidrosiform BP. 
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research

Related Links:

Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): Jelena Blagojevic, Paul Legendre, Marco Matucci-Cerinic, Luc MouthonAbstractIn systemic sclerosis (SSc), the use of corticosteroids (CS) is controversial due to their association with scleroderma renal crisis (SRC). However, patients with very early and early disease, characterised by main inflammatory component, may benefit from CS therapy.The aim of this review is to discuss pros and cons of CS treatment in SSc, providing current evidence about the use of CS in SSc. Moreover, we discuss also the underlying pathogenetic mechanisms tha...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
This study shows that dual species biofilms with foodborne pathogens are more resistant to disinfectant treatment than their single species counterparts and that biofilm maturity as well as environmental conditions, i.e. access to nutrients, play an important role in their response to the treatments tested.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Physics and Chemistry of SolidsAuthor(s): G. Palanisamy, K. Bhuvaneswari, A. Chinnadurai, G. Bharathi, T. PazhanivelAbstractSunlight driven photocatalysis is the next step of environmental remediation, which can utilize the renewable energy to cure environmental problems. Herein we report a magnetically recoverable ZnS/Ag/CoFe2O4 nanocomposite photocatalyst for sunlight driven photocatalytic dye degradation. The composition, structure, morphology, magnetic and photophysical properties of the as prepared samples were investigated by a wide range of charact...
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Molecular BiologyAuthor(s): Jieyu Tang, Yingchen Ju, Qiong Gu, Jun Xu, Huihao ZhouAbstractStaphyloferrin B is a hydroxycarboxylate siderophore that is crucial for the invasion and virulence of Staphylococcus aureus in mammalian hosts where free iron ions are scarce. The assembly of staphyloferrin B involves four enzymatic steps, in which SbnH, a pyridoxal 5’-phosphate (PLP)-dependent decarboxylase, catalyzes the second step. Here, we report the X-ray crystal structures of S. aureus SbnH (SaSbnH) in complex with PLP, citrate and the decarboxylation p...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
This report describes a 70-year-old woman with LPP who presented with extensive erosions mimicking TEN. This case also highlights the need to consider important etiologies such as drug-induced and paraneoplastic LPP.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Background: In US cystic fibrosis (CF) patients, methicillin-resistant Staphylococcus aureus (MRSA) rates have tripled in the past 2 decades. Known clinical risk factors include exposure to a healthcare setting, Pseudomonas aeruginosa and CF-related diabetes. Area-level socio-environmental exposures have not been evaluated. We explored the association of area-level deprivation with MRSA prevalence in a pediatric CF Center in the Southeastern United States. Methods: Patients’ residential addresses were geocoded and linked to a composite Area Deprivation Index and Rural-Urban Commuting Area scores. The association...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Authors: Macomb CV, Evans MO, Dockstater JE, Montgomery JR, Beakes DE Abstract Shoulder injury related to vaccine administration (SIRVA) is defined as "shoulder pain with limited range of motion within 48 hours after vaccine receipt in individuals with no prior history of pain, inflammation, or dysfunction of the affected shoulder before vaccine administration." Corticosteroid injections (CSIs) have been proposed as a reasonable treatment modality for SIRVA, although evidence regarding efficacy is scanty. In this case series, we present two patients diagnosed with SIRVA who received CSI within 5 days of s...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conclusions: It was estimated that the economic impact of a severe exacerbation in Spanish patients with severe asthma was €758.7/exacerbation. PMID: 31621441 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Publication date: Available online 18 October 2019Source: Physiology &BehaviorAuthor(s): Dennis F. Lovelock, Terrence DeakAbstractAdolescence is a developmental epoch marked by maturation of stress-responsive systems including the Hypothalamic-Pituitary-Adrenal (HPA) axis. Emerging evidence has found sex-specificity in the long term behavioral and neural effects of stressors experienced during this sensitive period, though most studies have utilized chronic stress exposures that span much of the adolescent period. Using Sprague-Dawley rats, we examined how a single exposure to inescapable footshock (80 shocks, 5s, 1.0 ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): Rasha A. Azzam, Galal H. Elgemeie, Rokia R. OsmanAbstractThe synthesis of novel pyrido[2,1-b]benzothiazole and pyrido[2,1-b]benzoimidazole derivatives was achieved via the reaction of N-aryl-2-cyano-3,3-bis(methylthio)acrylamide with benzothiazoleylacetonitrile and benzoimidazoleylacetonitrile, respectively, while N-substituted 2-pyridylbenzothiazole derivatives were synthesized by reacting 2-(benzo[d]thiazol-2-yl)-3-(dimethylamino)acrylonitrile with either cyanoacetamide, aryl cyanoacetamides or 2-cyano-N’-(4-substituted b...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
More News: Baclofen | Brain | Corticosteroid Therapy | Dermatology | Drugs & Pharmacology | Infectious Diseases | MRSA | Neurology | Pemphigoid | Skin | Staphylococcus Aureus | Superbugs