Post-traumatic bilateral blindness in a toddler

Publication date: Available online 19 September 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): E.W.M. Engelmann, C. Tinley, A.B. van AsAbstractA unique case of vision loss in a two-year-old boy after sustaining a head injury as a pedestrian versus car was seen at our paediatric trauma unit. A CT brain was negative for fracture, intra-cranial haemorrhage and contusion. There were no neurological symptoms and no signs of abuse. Ophthalmological examination demonstrated retinal haemorrhages, cotton wool spots and Purtscher flecken that are pathognomonic for the diagnosis of Purtscher's retinopathy. This occlusive microvasculopathy, associated with cranial and chest trauma, may cause severe blindness. In literature, bilaterality was described in almost two thirds of cases. Regardless of management with or without medication, visual function improved in the majority of cases. In our case, despite treatment with high-dose intravenous methylprednisolone, the child's vision remained poor with bilateral optic atrophy and retinal pigmentary changes. Children with Purtscher's retinopathy should be examined for signs of non-accidental injury.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research

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Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Authors: Kubo Y, Miki S, Akanuma SI, Hosoya KI Abstract The previous in vivo study revealed the carrier-mediated transport of riboflavin (vitamin B2) across the blood-retinal barrier (BRB). In the present study, the blood-to-retina supply of riboflavin across the outer BRB was assessed in RPE-J cells, a rat-derived in vitro cell model of the outer BRB that is formed by the retinal pigment epithelial cells. In the directional uptake analysis on collagen-coated Transwell® inserts, RPE-J cells showed higher basal-to-cell (B-to-C) uptake (22.8 μL/mg protein) of [3H]riboflavin than apical-to-cell (...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
Conclusion: Yellow fever vaccine may be a possible trigger for VKH. PMID: 31603703 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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