New medication advances treatment for chronic rhinosinusitis with nasal polyps

Chronic rhinosinusitis is a long-lasting medical condition, usually caused by infection or exposure to irritants, such as allergies, that affects one in seven American adults. Symptoms include nasal obstruction, nasal congestion, nasal drainage, loss of smell and taste, and facial pain and pressure. Some people with chronic rhinosinusitis also develop additional symptoms, such as asthma and nasal polyps, that are exacerbated by underlying allergies. A nasal polyp is a noncancerous tumor that grows from the lining of the nose or sinuses and affects the drainage system of the sinuses. While chronic rhinosinusitis is not a life-threatening condition, the chronic nature and progression of the disease can have a significant impact on quality of life, affecting work, productivity, and sleep, and leading to social and emotional consequences, such as depression and anxiety. Recently, a new medication has been approved in the treatment of chronic rhinosinusitis with nasal polyps. What is the new medication and how would it be used? Current treatment includes a combination of therapies that target symptoms. These include medical and surgical treatments, such as antibiotics, short-term oral corticosteroids, steroid nasal sprays, sinus irrigation, and endoscopic sinus surgery. However, many people continue to experience symptoms despite treatment. Earlier this year, the FDA approved dupilumab (Dupixent) to treat chronic rhinosinusitis with nasal polyps that is not adequately controlled w...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Cold and Flu Drugs and Supplements Ear, nose, and throat Health Source Type: blogs

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Authors: Hodzic-Santor BH, Meltzer JA, Verhoeff NPLG, Blumberger DM, Mah L PMID: 32950361 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
AbstractPhotobiomodulation (PBM) has been used to modulate the inflammatory and immune responses, pain relief, and to promote wound healing. PBM is widely used in dental practice and its cellular effects should be investigated. The aim was to evaluate if PBM changes proteins cell death –related, such as caspase-6 and Bcl-2, in periodontal ligament cells. Eighteen mice were divided in three groups (n = 6), i.e., (I) control, (II) 3 J cm−2, and (III) 30 J cm−2. Low power infrared laser (830 nm) parameters were power at 10 mW, energy densities at 3 and 30 J cm−2 in continuous emission mode, exposure ti...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Transcription infidelity (TI) is a mechanism that increases RNA and protein diversity. We found that single-base omissions (i.e., gaps) occurred at significantly higher rates in the RNA of highly allergenic legumes. Transcripts from peanut, soybean, sesame, and mite allergens contained a higher density of gaps than those of nonallergens. Allergen transcripts translate into proteins with a cationic carboxy terminus depleted in hydrophobic residues. In mice, recombinant TI variants of the peanut allergen Ara h 2, but not the canonical allergen itself, induced, without adjuvant, the production of anaphylactogenic specific IgE...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This study has the potential to transform the diagnosis and treatment of allergic disorders.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Conclusion: Findings suggest that DMRT3 could be potentially involved in nasal polyps development in N-ERD patients. Known functions of DMRT3 include nucleic acid binding and highly expressed during embryonic development. Several genes are downregulated, hinting dedifferentiation phenomenon in N-ERD polyps. However, further studies are required to confirm the exact mechanism of polyps formation in N-ERD patients.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Patellar instability and associated patellar dislocation can result in significant pain, disability, and associated injuries in young athletes. The patellofemoral joint is a complex articulation with stabilizing restraints, both medially and laterally, tha...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Suicide rates are on the rise globally. Many suicide completers are previous attempters. Risk identification of attempters will provide an opportunity for prompt and targeted intervention towards suicide prevention. The aim of this study was to...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
When will we go back to dinners and drinks with reps, thought leader "focus groups," Instagram whoring, etc?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Conclusion: It is a diagnostic challenge when recurrent branch retinal artery occlusion secondary to Susac syndrome presents without the classic symptoms. Optical coherence tomography angiography and subtle magnetic resonance imaging findings aided in early recognition of the diagnosis in our patient. Ultra-wide-field fluorescein angiography was an important tool in disease monitoring. Aggressive management with intravenous corticosteroids and initiation of immunosuppression resulted in long-term preservation of vision and improvement in visual field.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
Publication date: Available online 21 September 2020Source: International Journal of Nursing SciencesAuthor(s): Xuelian Liu, Li Li, Lingxiao Wang, Keela Herr, Qiuchan Chen
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
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