The association of maternal iodine status in early pregnancy with thyroid function in the SELMA study.
This study was embedded within the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Clinical reference ranges were determined by the 2.5th and 97.5th population-based percentile cut-offs. The associations of UI/Creat with thyrotropin (TSH), free T4 (FT4), free triiodothyronine (FT3), total T4 (TT4), total triiodothyronine (TT3) were studied using multivariable linear regression in TPOAb negative women. The association of UI/Creat with TPOAb and TgAb positivity was analyzed using multivariable logistic regression. RESULTS: Urinary iodine and thyroid function were measured at a median (95% range) gestational age of 10 (6-14) weeks in 2009 women. The median (95% range) UI/Creat was 85 µg/g (36-386) and the UI/Creat was below 150 µg/g in 80.1% of women. Reference ranges did not differ substantially by UI/Creat. A lower UI/Creat was associated with a lower TSH (P=0.027), a higher TT4 (P=0.032), and with a corresponding trend towards slightly higher FT4 (P=0.081), FT3 (P=0.079), and TT3 (P=0.10). UI/Creat was not associated with the FT4/FT3 (P=0.94) or TT4/TT3 ratios (P=0.63). Women with a UI/Creat of 150-249 µg/g had the lowest prevalence of TPOAb positivity (6.1%), while women with a UI/Creat of
Hydroxychloroquine (HCQ, Plaquenil ®) is an antimalarial agent with immunosuppressive and cytotoxic properties that is considered safe and effective in pregnant patients with a history of mild lupus nephritis (LN).1-2 Hypersensitivity to hydroxychloroquine usually manifests as maculopapular exanthems within two to 33 days and rarely as eosinophilia or other systemic symptoms.3 Several prolonged desensitization protocols, ranging from four to 36 days in duration, have been proposed to manage prior histories of HCQ hypersensitivity.
Thyroid, Ahead of Print.
ConclusionAs new data arise, revisions might soon be needed allowing AIT in the cases of patients treated with ACE inhibitors and beta-blockers, in elderly patients and in patients with concomitant autoimmune diseases and neoplasias in remission. The decision to prescribe AIT is always tailor-made, balancing risk vs benefit. Creating globally accepted guidelines would help Allergologists in their decision making.
Publication date: Available online 5 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kathleen A. Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O’Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Sheryl L. Rifas-Shiman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. Allergic reactions to foods often occur on the first known ingestion, suggesting that exposure of offspring to food allergens may occur in utero and/or through breast milk. This creates a milieu that shapes the neonatal immune response to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances ...
The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...
ConclusionsThe benefits of FENO-based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Asthma is often not well controlled during pregnancy, especially among publicly-insured women, according to a U.S. study.Reuters Health Information
ConclusionsThe benefits of FENO -based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
CONCLUSIONS: Outcome-specific criteria are an important part of a systematic review and will facilitate study evaluations by epidemiologists with experience in evaluating studies using systematic review methods who may not have extensive discipline-specific experience in the outcomes being reviewed. PMID: 31299560 [PubMed - as supplied by publisher]