Featured Review: Imaging with PET during chemotherapy to predict outcome in adults with Hodgkin lymphoma

The objective of this review was to determine whether in previously untreated adults with HL (all stages) receiving first-line therapy, interim PET scan results (i.e. a positive or a negative result) can distinguish between those with a poor prognosis and those with a better prognosis, and thereby predict survival in each group.How many studies were included? What was included and what was excluded?We included twenty-three studies in total, in this review. In all studies, interim PET was conducted during first-line therapy and after two, three, and/or four cycles of chemotherapy in adults with HL (all stages). We included both retrospective and prospective studies that provided evidence on our prognostic factor of interest (interim PET-scan results) and outcomes of interest (overall survival, progression-free survival and PET-associated adverse events). It was important to include studies in which the treatment regimen of the participants was not adapted according to the interim PET scan results. In other words, irrespective of the interim PET scan result (interim PET-positive or interim PET-negative), participants should continue with the same treatment regimen as specified at the beginning of the study. The reason being that the occurrence of the predicted outcome in each group shall be attributable to the prognostic factor of interest (the interim PET scan result) rather than the modified treatments. Hence, we excluded studies that in their design allowed adaptation of the...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

Related Links:

Wavefront shaping makes it possible to form a focus through opaque scattering materials. In some cases, this focus may be scanned over a ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
Publication date: Available online 16 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): V. Arpudhamary, S. Priya, Muhammed A.P. Manzoor, D. Mubarakali, S. HemalathaAbstractCancer is a group of diseases characterized by the rapid creation of abnormal cells. Cancer is one of the leading causes of death in humans, affecting millions of people per year. Cembranoids are carbocyclic diterpenes composed of 14-membered ring, mainly present in the genera Nicotiana and Pinus in plants, and soft coral and other organisms. Cembranoids are cytotoxic and inhibit phospholipid metabolism. The present study is focus...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 16 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Bahgat Fayed, Hoda S. El-Sayed, Amira Abood, Amal M. Hashem, Nayra S.H. MehannaAbstractThe potential application for the multiparticulate synbiotic microcapsule in yoghurt production was presented in the current study. Initially, three different formulae were fabricated to investigate the mechanism of action. This was followed by characterization the size of both of the nanoparticles and the final multiparticulate microcapsule. The yoghurt was then formed and the formulae were added and subjected to 4 weeks stora...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
In this study, new peripheral tetra-4-butylmorpholine substituted zinc(II) phthalocyanine was synthesized through C–C bond formation using the palladium catalyzed Suzuki-Miyaura coupling reaction. Its structure was characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, UV–vis, fluorescence, and MALDI-TOF-mass spectroscopic techniques. Its thermal property were evaluated by thermogravimetric analysis and differential scanning calorimetry. In addition, the photophysical properties of the zinc(II) phthalocyanine were also investigated in DMSO.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, 3D Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were employed to construct quantitative structure-activity relationship (QSAR) models of a series of niacinamide analogues as antiandrogens. The obtained models have good reliability and predictivity. In addition, the contour maps from the models can intuitively aid to understand the vital structural characteristics of niacinamides related with the AR antagonistic activities. Our study provides important guidance for the rational design and screening of highly potential active antiandrogens.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
CONCLUSION: The results of the Keynote-048 study have already led to the approval of pembrolizumab in the first line for platin-sensitive HNSCC in the USA and the expected approval in Europe will presumably change the therapeutic landscape in the long term. In the future, effective therapies for patients without a response to programmed cell death 1 (PD-1)/PD-L1 inhibition will be needed. PMID: 31612261 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Publication date: Available online 16 October 2019Source: Process BiochemistryAuthor(s): Raedah A.S. Alatawi, M. Monier, Nadia H. ElsayedAbstractIn this work, a photo-responsive hydrogel membrane based on cinnamate-modified hyaluronic acid (HA-CM) was developed and safely cross-linked under UV light curing. The obtained material was effectively utilized for immobilization of horseradish peroxidase (HRP) enzyme via encapsulation and entrapment strategy with efficiency above 95%. The prepared HA-CM biopolymer was investigated before the UV curing using instrumental and spectral techniques including Fourier transform infrared...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 16 October 2019Source: Chemico-Biological InteractionsAuthor(s): Yasmeen M. Attia, Dina M. El-Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, Nada Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed Tarek Mansour, Mohamed M. ElmazarAbstractTreatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance. Increased aldehyde dehro...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 16 October 2019Source: Reactive and Functional PolymersAuthor(s): Xia Wang, Qihui Chen, Yangqing Zheng, Maochun Hong, Heqing FuAbstractFirst, Layered double hydroxide (LDH) was modified by toluene diisocyanate (TDI), 2-hydroxyethyl acrylate (HEA), and LDH-TDI-HEA was prepared. Then LDH-TDI-HEA was modified by vinyl triethoxysilane (VTES), and LDH-TDI-HEA-VTES composites were obtained. Finally, acrylate was modified by LDH-TDI-HEA-VTES, and flame retarded LDH-TDI-HEA-VTES-Acrylate composites were successfully synthesized by in situ polymerization. The structures of LDH, LDH-TDI-HEA, LDH-TD...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
Publication date: Available online 17 October 2019Source: PolymerAuthor(s): Subramaniyan Ramasundaram, Ashiqur Rahaman, Byungki KimAbstractA 96% β-crystalline poly(vinylidene fluoride) nanofibers (PVDF NFs) were prepared by collecting electrospun NFs on a roller operated at 5000 rpm, followed by annealing at 150 °C. Dodecylamine functionalized non-polar silver nanoparticles (Ag NPs) were synthesized. The Ag NPs were brush coated on a PVDF NFs support and used as an electrode to demonstrate a piezoelectric sensor (PS). PVDF NFs was characterized with Fourier-transform infrared spectroscopy (FTIR), X-ray diffrac...
Source: Polymer - Category: Chemistry Source Type: research
More News: Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cardiology | Chemotherapy | Databases & Libraries | Education | Germany Health | Heart | HIV AIDS | Hodgkin's Disease | Information Technology | Lymphoma | Men | PET Scan | Study | Toxicology | Universities & Medical Training