Fast emerging insecticide resistance in Aedes albopictus in Guangzhou, China: Alarm to the dengue epidemic

In this study,Ae.albopictus were collected from four districts with varied dengue virus transmission intensity in Guangzhou from 2015 to 2017. AdultAe.albopictus insecticide susceptibility to deltamethrin (0.03%), permethrin(0.25%), DDT(4%), malathion (0.8%) and bendiocarb (0.1%) was determined by the standard WHO tube test, and larval resistance bioassays were conducted using temephos,Bacillus thuringiensis israelensis (Bti), pyriproxyfen (PPF) and hexaflumuron. Mutations at the voltage-gated sodium channel (VGSC) gene and acetylcholinesterase (AChE) gene were analyzed. The effect of cytochrome P450s on the resistance ofAe.albopictus to deltamethrin was tested using the synergistic agent piperonyl butoxide (PBO). The results showed thatAe.albopictus populations have rapidly developed very high resistances to multiple commonly used insecticides at all study areas except malathion,Bti and hexaflumuron. We found 1534 codon mutations in the VGSC gene that were significantly correlated with the resistance to pyrethroids and DDT, and 11 synonymous mutations were also found in the gene. The resistance to deltamethrin can be significantly reduced by PBO but may generated cross-resistance to PPF. Fast emerging resistance inAe.albopictus may affect mosquito management and threaten the prevention and control of dengue, similar to the resistance inAnopheles mosquitoes has prevented the elimination of malaria and call for timely and guided insecticide management.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Date: Tuesday, 11 26, 2019; Speaker: Susan Pierce, Ph.D., Chief, Laboratory of Immunogenetics, NIAID; Building: 35; GF640
Source: NIH Calendar of Events - Category: American Health Source Type: events
ConclusionsFrom the results it can be concluded that there indeed exists correlation between striking and struck vehicles in side crashes, although the correlation is not so strong. Importantly, Bayesian bivariate probit model can address the role of striking and struck vehicles in side crashes simultaneously and can accommodate the correlation clearly, which extends the range of univariate probit analysis. The general and empirical countermeasures are presented to improve the safety at intersections.
Source: Accident Analysis and Prevention - Category: Accident Prevention Source Type: research
Publication date: Available online 21 October 2019Source: Materials Today: ProceedingsAuthor(s): P.G. Venkatakrishnan, V. KarthikAbstractThe electroless Ni-B alloy coatings are prepared using an alkaline plating bath with nickel chloride as the source of nickel ions and sodium borohydride as the reducing agent as well as the source of boron ions in presence of zinc acetate in the plating bath. The effect zinc acetate concentration on plating rate, chemical composition, surface morphology, structural characteristics, hardness and wear properties of the electroless Ni-B alloy coatings are evaluated. The boron content in the ...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 21 October 2019Source: Materials Science and Engineering: CAuthor(s): Daniel de Castro Girão, Miloslav Béreš, André Luiz Jardini, Rubens Maciel Filho, Cleiton Carvalho Silva, Abner de Siervo, Hamilton Ferreira Gomes de Abreu, Walney Silva AraújoAbstractCoCrMo alloys have been used for several decades in implantable devices due to their favourable mechanical properties, low wear rate in addition to good biocompatibility and high corrosion resistance. These alloys are conventionally produced via casting and/or forging route, however additive manufacturing ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 22 October 2019Source: Food Quality and PreferenceAuthor(s): Xuefei Li, Yuxuan Qi, Charles Spence, Xiaoang WanAbstractTwo studies were conducted in order to investigate the influence of teaware on consumers’ subjective ratings of, and taste expectations concerning, one of the world’s most popular beverages, namely tea. In Study 1, 100 Chinese participants and 100 participants from the USA viewed online photographs of Chinese brand and British brand green tea presented in either Chinese or British tea sets. The participants then rated their feelings about, taste expectations co...
Source: Food Quality and Preference - Category: Food Science Source Type: research
Publication date: Available online 22 October 2019Source: Antiviral ResearchAuthor(s): Esther Oiknine-Djian, Shikma Bar-On, Ido Laskov, Daniel Lantsberg, Richard K. Haynes, Amos Panet, Dana G. WolfAbstractWe have recently shown that the artemisinin derivative artemisone, which was screened against malaria in human clinical studies, is a potent inhibitor of human cytomegalovirus (HCMV). Here we evaluated the antiviral effect of artemisone when employed in 2-drug combinations with approved and experimental anti-HCMV agents. Using the Chou-Talalay method, we found that in-vitro combination of artemisone with cidofovir, brinci...
Source: Antiviral Therapy - Category: Virology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
DAVID E. BLOOM is the Clarence James Gamble Professor of Economics and Demography, DANIEL CADARETTE is a research assistant, and JP SEVILLA is a research associate, all at Harvard University’s T.H. Chan School of Public Health.By David E. Bloom, Daniel Cadarette and JP SevillaWASHINGTON DC, Jul 3 2018 (IPS)Infectious diseases and associated mortality have abated, but they remain a significant threat throughout the world.We continue to fight both old pathogens, such as the plague, that have troubled humanity for millennia and new pathogens, such as human immunodeficiency virus (HIV), that have mutated or spilled over ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Active Citizens Development & Aid Economy & Trade Global Headlines Health TerraViva United Nations Source Type: news
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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