A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe

Non-alcoholic fatty liver disease (NAFLD) is a growing challenge to global public health. It is defined as the increased accumulation of hepatic triglyceride (>5%) in the absence of excessive alcohol consumption or other causes of liver disease. The NAFLD spectrum encompasses steatosis (non-alcoholic fatty liver, NAFL) and non-alcoholic steatohepatitis (NASH), an inflammatory form of the condition marked by the presence of hepatocyte damage and progressive fibrosis that may lead to cirrhosis.[1,2] Although NAFLD may occur in patients with normal weight, it is closely associated with the presence of the metabolic syndrome, and therefore with obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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ConclusionsCB1R was widely distributed in multiple hypothalamic nuclei. The expression of CB1R was augmented only when mice were treated with HFD and nicotine in combination. These data suggest that the exposure to nicotine may provoke an enhanced endocannabinoid response in diet-induced obesity.Graphical abstract
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionsWith the application of a dual model, there appears to be no significant difference in mortality of obese patients with pneumonia compared to normal BMI patients with pneumonia.
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Experimental Child PsychologyAuthor(s): Veronica Guardabassi, Carlo TomasettoAbstractThe high prevalence of childhood obesity has drawn increasing attention to the neurocognitive impairments associated with excess weight, and evidence has accumulated of a progressive decline in working memory at increasing levels of children’s Body Mass Index (BMI). However, obesity is also a highly stigmatizing condition, and pervasive societal stereotypes depict individuals with obesity as less intelligent than those with average weight. For this reason, we invest...
Source: Journal of Experimental Child Psychology - Category: Child Development Source Type: research
Publication date: November 2019Source: Infant Behavior and Development, Volume 57Author(s): Stephanie D’Souza, Caitlin N. Crawford, Jude Buckley, Lisa Underwood, Elizabeth R. Peterson, Amy Bird, Susan M.B. Morton, Karen E. WaldieAbstractThe determinants of talking delay alone or its comorbidity with behavioural difficulties was examined in 5768 two-year-old members of the Growing Up in New Zealand longitudinal study. Using the MacArthur-Bates Communicative Development inventories and the total difficulties score from the preschool Strengths and Difficulties Questionnaire, a composite measure was created so that child...
Source: Infant Behavior and Development - Category: Child Development Source Type: research
Publication date: Available online 15 October 2019Source: Food Research InternationalAuthor(s): Mohammed Bule, Shekoufeh Nikfar, Mohsen Amini, Mohammad AbdollahiAbstractThymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ) is a quinone derivative with a yellow crystalline appearance, abundantly found in black cumin, Nigella sativa L. TQ has diverse pharmacological properties. The aim of this systematic review on the antidiabetic effects of TQ is to evaluate the currently available evidence and conduct meta-analysis. A literature search of articles published until 25 January 2019 was done on PubMed, EMBASE, Web of Scie...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 9 October 2019Source: Food Research InternationalAuthor(s): Dave Jaydeep Pinakin, Vikas Kumar, Sheenam Suri, Rakesh Sharma, Manisha KaushalAbstractA numerous types of tree flowers are present in nature and few of them such as Rhdodendron, Bauhinia, Mahua, Gulmohar, Palash, Sesbania, Woodfordia, Simbal, etc. are being utilized traditionally as food and medicine by the localities of India. These flowers are rich in phytochemical (flavonoids, anthocyanins, phenolic acids, carotenoids, tannins, saponins) and possessing numerous health benefits (antioxidant activity, anti-inflammation, anti-ca...
Source: Food Research International - Category: Food Science Source Type: research
This study evaluates the effects of a chemically characterized polyphenolic extract of H. sabdariffa (HSE) in an experimental model of diet-induced obesity (DIO) in mice. HSE was administered daily by oral gave for 42 days. HSE reduced weight increase in high fat diet (HFD)-fed mice, and improved glucose tolerance, insulin sensitivity and normalized LDL/HDL cholesterol ratio. It also enhanced the inflammatory state in the liver, reducing the expression of different adipokines and proinflammatory mediators, and reinforced gut integrity by increasing the expression of mucins and proteins involved in the maintenance of mucosa...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 8 October 2019Source: Food Research InternationalAuthor(s): Antonio Higinio Sánchez, Antonio López-López, Amparo Cortés-Delgado, Antonio de Castro, Alfredo MontañoAbstractThe aroma profile and volatile composition of 8 samples of black ripe olives from Manzanilla and Hojiblanca cultivars were analyzed with the aim to characterize this type of table olive. The aroma of samples was described by a sensory panel using quantitative descriptive analysis (QDA), whereas the volatiles were analyzed by headspace solid-phase microextraction (HS-SPME) followed by ga...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 18 October 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Felicity E. Lumb, Jenny Crowe, James Doonan, Colin J. Suckling, Colin Selman, Margaret M. Harnett, William HarnettAbstractOne of the most rapidly increasing human public health problems is obesity, whose sequelae like type-2 diabetes, represent continuously worsening, life-long conditions. Over the last 15 years, data have begun to emerge from human and more frequently, mouse studies, that support the idea that parasitic worm infection can protect against this condition. We have therefore investigated the potential of...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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