Defining the molecular evolution of extrauterine high grade serous carcinoma.

CONCLUSION: This study provides strong evidence suggesting that extrauterine HGSC arises from the fimbria of the distal fallopian tube. Furthermore, several potential pathways were identified which could be targeted by novel therapies for HGSC. These findings have significant translational relevance for both primary prevention and clinical management of the disease.
PMID: 31493898 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - September 3, 2019 Category: Cancer & Oncology Authors: Beirne JP, McArt DG, Roddy A, McDermott C, Ferris J, Buckley NE, Coulter P, McCabe N, Eddie SL, Dunne PD, O'Reilly P, Gilmore A, Feeney L, Ewing DL, Drapkin RI, Salto-Tellez M, Kennedy RD, Harley IJG, McCluggage WG, Mullan PB Tags: Gynecol Oncol Source Type: research